A Human Cardiomyocyte Screen Identifies Optimized Lipid Nanoparticles for In Vivo Cardiac Gene Editing

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Researchers developed a screening platform using hiPSC–derived cardiomyocytes to identify human cardiotropic lipid nanoparticles (LNPs). By screening a chemically diverse LNP library, they identified a lead LNP, 18:1 TAP10, with potent human cardiac transfection capability.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract