Deficiency of Muscular Dystrophy-Related Gene JAG2 Causes NOTCH Signaling Dysfunction in Muscle Stem Cells

Investigators examined the consequences of Jagged2 JAGGED2 (JAG2) deficiency and modeled pathogenic JAG2 variants in vitro and in vivo, the latter in mouse and fly models and with particular attention to the muscle stem cell-muscle endothelial cell niche.