Extracellular Matrix-Targeted Biomaterials and Nanocarriers for Pelvic-Floor Repair/Regeneration in Stress Urinary Incontinence: Local Modulation of the MMP/TIMP Axis and NF-B/MAPK-Linked Remodelling Programs

The authors frames stress urinary incontinence as a clinically relevant ECM-failure niche and synthesises ECM-targeted biomaterials and nanocarriers designed to rebalance the MMP/TIMP axis while enabling pragmatic pharmacodynamic readouts for early translation.