Transplantation Tolerance Versus Immune Evasion: Mechanistic Divergences and Therapeutic Frontiers for Islet Cell Replacement

Transplantation tolerance, a recipient-centric strategy, utilizes central deletional processes through mixed hematopoietic chimerism and thymic repertoire sculpting, complemented by peripheral mechanisms such as T cell anergy, exhaustion, apoptotic deletion, and Treg dominance.