Newsletters

[Scientific Reports] Researchers evaluated the effect of ultrashort wave therapy on enhancing jaw bone marrow MSC function and promoting mandibular repair.

[European Journal of Pharmacology] The authors summarize the therapeutic significance of MSCs for inflammatory bowel disease in the context of their interactions with various innate and adaptive immune cells, including neutrophils, monocytes/macrophages, dendritic cells, natural killer cells, B lymphocytes, and T lymphocytes.

[Stem Cell Research & Therapy] Investigators proposed that placenta-derived choriodecidual MSCs may confer an additive survival benefit after severe burn injury, particularly under inadequate fluid resuscitation and thermal support.

[International Journal of Oral Science] Investigators demonstrated that highly branched poly(β-amino ester)-mediated metabolic reprogramming effectively rejuvenates mature dental pulp stem cells by restoring the metabolic-ECM-angiogenesis axis.

[Signal Transduction and Targeted Therapy] Researchers observed that MSCs, specifically bone marrow derived-MSCs, mitigated mitochondrial dysfunction during the early stages of ischemia-reperfusion injury-related acute kidney injury, leading to reduced inflammation, preventing cellular injury and recovery of renal function.

[Cell Stem Cell] Scientists established a clinically compliant, extracellular vesicle (EV)-enriched secretome derived from bone marrow-derived-MSCs and assessed its immunomodulatory capacity in vitro, along with its cardioprotective efficacy in blinded, placebo-controlled, and clinically relevant murine and porcine models of myocardial ischemia-reperfusion injury.

[Jacksonville State University] Jacksonville State University Assistant Professor of Biology Dr. Le Su has received a $73,003.37 Extended Scholar Grant from the St. Baldrick’s Childhood Cancer Research Foundation to support research centered on CIC-DUX4 sarcoma, a rare soft tissue cancer that primarily affects children and young adults.

[International Immunopharmacology] Researchers investigated the therapeutic potential and underlying mechanisms of interleukin-1 receptor antagonist overexpressing MSCs (oeIL-1Ra-MSCs) in a murine acute lung injury model. They demonstrated that oeIL-1Ra-MSCs attenuated pulmonary pathology in murine models, reduce inflammatory responses, and mitigate alveolar epithelial cell damage.

[Blood] Investigators introduced clonal Hematopoietic stem and progenitor cell tracker (cHSPCTrack), an in vitro framework for serially tracking clonal differentiation and fate acquisition from human HSPCs extracted from circulation.

[Blood] In this study, researchers conditionally deleted Mll3, Mll4, or both genes together to determine how each gene controls divergent hematopoietic stem cell fate decisions.

[Cancer Research] Investigators developed and evaluated PinA1, a molecular glue degrader targeting casein kinase 1⍺ (CK1⍺), in preclinical AML models.

[Leukemia] Researchers identified ACSF2 as a key metabolic determinant of cytarabine (Ara-C) resistance. ACSF2 inhibition suppresses Ara-C-resistant AML cell proliferation, restores Ara-C sensitivity in vitro and in vivo.