SNED1 Modulates ECM Architecture and Cell Proliferation via Its LDV Integrin-Binding Motif Icon for the Forest of Biologists

Researchers investigated the role of SNED1–integrin interactions in SNED1 ECM assembly. They found that the LDV motif, but not the RGE motif, in SNED1, was required for ECM build-up and the patterning of SNED1 and the fibrillar proteins fibronectin and collagen.