TRIM25 Facilitates Mitochondrial Dysfunction and Extracellular Matrix Degradation by Enhancing USP7-Driven ENO1 Deubiquitination during Intervertebral Disc Degeneration

The authors employed cellular and in vivo animal models to validate the effects of the TRIM25-USP7-ENO1 axis on glycolysis, mitochondrial function, ATP levels, and ECM degradation.