Emerging Routes to the Generation of Functional β-Cells for Diabetes Mellitus Cell Therapy

By
Justin.choi
-
0
129
Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice.
[Nature Reviews Endocrinology]
1254621 {1254621:PCPWC4SQ} 1 apa 50 default 1 151124 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22PCPWC4SQ%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nair%20et%20al.%22%2C%22parsedDate%22%3A%222020-06-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNair%2C%20G.%20G.%2C%20Tzanakakis%2C%20E.%20S.%2C%20%26amp%3B%20Hebrok%2C%20M.%20%282020%29.%20Emerging%20routes%20to%20the%20generation%20of%20functional%20%26%23x3B2%3B-cells%20for%20diabetes%20mellitus%20cell%20therapy.%20%26lt%3Bi%26gt%3BNature%20Reviews%20Endocrinology%26lt%3B%5C%2Fi%26gt%3B%2C%201%26%23x2013%3B13.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41574-020-0375-3%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41574-020-0375-3%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3Ba%20title%3D%26%23039%3BCite%20in%20RIS%20Format%26%23039%3B%20class%3D%26%23039%3Bzp-CiteRIS%26%23039%3B%20data-zp-cite%3D%26%23039%3Bapi_user_id%3D1254621%26amp%3Bitem_key%3DPCPWC4SQ%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BCite%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Emerging%20routes%20to%20the%20generation%20of%20functional%20%5Cu03b2-cells%20for%20diabetes%20mellitus%20cell%20therapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gopika%20G.%22%2C%22lastName%22%3A%22Nair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%20S.%22%2C%22lastName%22%3A%22Tzanakakis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Hebrok%22%7D%5D%2C%22abstractNote%22%3A%22Diabetes%20mellitus%2C%20which%20affects%20more%20than%20463%20million%20people%20globally%2C%20is%20caused%20by%20the%20autoimmune%20ablation%20or%20functional%20loss%20of%20insulin-producing%20%5Cu03b2-cells%2C%20and%20prevalence%20is%20projected%20to%20continue%20rising%20over%20the%20next%20decades.%20Generating%20%5Cu03b2-cells%20to%20mitigate%20the%20aberrant%20glucose%20homeostasis%20manifested%20in%20the%20disease%20has%20remained%20elusive.%20Substantial%20advances%20have%20been%20made%20in%20producing%20mature%20%5Cu03b2-cells%20from%20human%20pluripotent%20stem%20cells%20that%20respond%20appropriately%20to%20dynamic%20changes%20in%20glucose%20concentrations%20in%20vitro%20and%20rapidly%20function%20in%20vivo%20following%20transplantation%20in%20mice.%20Other%20potential%20avenues%20to%20produce%20functional%20%5Cu03b2-cells%20include%3A%20transdifferentiation%20of%20closely%20related%20cell%20types%20%28for%20example%2C%20other%20pancreatic%20islet%20cells%20such%20as%20%5Cu03b1-cells%2C%20or%20other%20cells%20derived%20from%20endoderm%29%3B%20the%20engineering%20of%20non-%5Cu03b2-cells%20that%20are%20capable%20of%20modulating%20blood%20sugar%3B%20and%20the%20construction%20of%20synthetic%20%5Cu2018cells%5Cu2019%20or%20particles%20mimicking%20functional%20aspects%20of%20%5Cu03b2-cells.%20This%20Review%20focuses%20on%20the%20current%20status%20of%20generating%20%5Cu03b2-cells%20via%20these%20diverse%20routes%2C%20highlighting%20the%20unique%20advantages%20and%20challenges%20of%20each%20approach.%20Given%20the%20remarkable%20progress%20in%20this%20field%2C%20scalable%20bioengineering%20processes%20are%20also%20discussed%20for%20the%20realization%20of%20the%20therapeutic%20potential%20of%20derived%20%5Cu03b2-cells.%22%2C%22date%22%3A%222020-06-25%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41574-020-0375-3%22%2C%22ISSN%22%3A%221759-5037%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41574-020-0375-3%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-06-25T16%3A29%3A49Z%22%7D%7D%5D%7D
Nair, G. G., Tzanakakis, E. S., & Hebrok, M. (2020). Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy. Nature Reviews Endocrinology, 1–13. https://doi.org/10.1038/s41574-020-0375-3 Cite
Abstract