Exosomes Derived from Placental Trophoblast Cells Regulate Endometrial Epithelial Receptivity in Dairy Cows during Pregnancy

Bovine trophoblast cells were obtained from bovine placenta and immortalized by transfection with telomerase reverse transcriptase. Scientists demonstrated that trophoblast-derived exosome proteins were one of the most critical elements in fetomaternal interaction, and their changes might act as a key signal in altering endometrial receptivity and provided a potential target for improving fertility.