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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
USP19 Potentiates Autophagic Cell Death via Inhibiting mTOR Pathway through Deubiquitinating NEK9 in Pancreatic Cancer
[Cell Death & Differentiation] Scientists identified that ubiquitin-specific protease 19 (USP19) was downregulated in pancreatic tumor tissues and forced expression of USP19 diminished tumorigenicity of pancreatic cancer.
Spint1 Disruption in Mouse Pancreas Leads to Glucose Intolerance and Impaired Insulin Production Involving HEPSIN/MAFA
[Nature Communications] Researchers generated Spint1-lacZ knock-in mice and observed Spint1 expression in embryonic pancreatic epithelium. Pancreas-specific Spint1 disruption significantly diminished islet size and mass, causing glucose intolerance and downregulation of MAF bZIP transcription factor A (MAFA) and insulin.
Aldehyde Dehydrogenase-1A1 (ALDH1A1): The Novel Regulator of Chemoresistance in Pancreatic Cancer Cells
[Cancer Control] The authors summarize the clinical functions of ALDH1A1 as a novel regulator of chemoresistance, prognosis, and cancer stem cell development in pancreatic cancer.
New Therapy from UI Health Offers FDA-Approved Treatment Option for Brittle Type 1 Diabetes
[University of Illinois (UI) Health] A new therapy for brittle type 1 diabetes, the only treatment currently approved by the US FDA, is available exclusively at UI Health in Chicago.
Long-Term In Vitro Expansion of a Human Fetal Pancreas Stem Cell That Generates All Three Pancreatic Cell Lineages
[Cell] Researchers reported derivation of 18 human fetal pancreas organoid lines from gestational weeks 8–17 fetal pancreas samples. Four of these lines generated acinar-, ductal-, and endocrine-lineage cells while expanding exponentially for >2 years under optimized culture conditions.
Hyperaminoacidemia from Interrupted Glucagon Signaling Increases Pancreatic Acinar Cell Proliferation and Size via mTORC1 and YAP/TAZ Pathways
[iScience] By genetic and pharmacological disruption of glucagon receptor in mice and zebrafish, scientists reported that the ensuing hyperaminoacidemia promoted pancreatic acinar cell proliferation and cell hypertrophy, which could be mitigated by a low protein diet in mice.
Exacerbated Ischemic Brain Damage in Type 2 Diabetes via Methylglyoxal-Mediated miR-148a-3p Decline
[BMC Medicine] Using type 2 diabetesmodels generated with streptozotocin plus a high-fat diet or db/db mice, and then inducing focal ischemic stroke through middle cerebral artery occlusion and reperfusion, scientists established a diabetic stroke mouse model.
Role of the Pancreatic Islet Microvasculature in Health and Disease
[Journal of Histochemistry & Cytochemistry] In type 2 diabetes, the islet vasculature becomes inflamed, showing loss of endothelial cells, detachment, and/or trans-differentiation of pericytes, vessel dilation, and excessive extracellular matrix deposition.
OU College of Medicine Professor Earns Prestigious Pancreatology Award
[OU News] Dr. Min Li at the University of Oklahoma (OU) College of Medicine will receive the 2024 Palade Prize from the International Association of Pancreatology. This award recognizes Dr. Li’s contributions to the field of pancreatology, which is dedicated to discovering new methods of identifying, diagnosing, and treating diseases of the pancreas.
Spatial Interactions of Immune Cells as Potential Predictors to Efficacy of Toripalimab plus Chemotherapy in Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma: A Phase...
[Signal Transduction and Targeted Therapy] This Phase Ib/II study evaluated the safety and efficacy of combining toripalimab with the gemcitabine plus nab-paclitaxel regimen as first-line treatment for locally advanced or metastatic PDAC and explored predictive biomarkers.
Inceptor Binds to and Directs Insulin Towards Lysosomal Degradation in β Cells
[Nature Metabolism] Using human induced pluripotent stem cell (SC)-derived islets, the authors showed that IIR knockout (KO) resulted in enhanced SC β cell differentiation and survival. Extended in vitro culture of IIR KO SC β cells led to greatly increased insulin content and glucose-stimulated insulin secretion.
Reformed Islets: A Long-Term Primary Cell Platform for Exploring Mouse and Human Islet Biology
[Cell Death Discovery] While primary islets, the gold standard for in vitro models, have a short culture life of approximately one-two weeks, researchers developed a protocol that employed reformed islets following dispersion coupled with a fine-tuned culture environment.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
