Autophagy Augments the Self-Renewal of Lung Cancer Stem Cells by the Degradation of Ubiquitinated p53

By generating stable human lung cancer stem cell (CSC) cell lines with the wild-type TP53, as well as cell lines in which TP53 was deleted, the authors showed, for the first time, that autophagy augments the stemness of lung CSCs by degrading ubiquitinated p53.
[Cell Death & Disease]
Wang, J., Liu, D., Sun, Z., Ye, T., Li, J., Zeng, B., Zhao, Q., & Rosie Xing, H. (2021). Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53. Cell Death & Disease, 12(1), 1–12. https://doi.org/10.1038/s41419-021-03392-6 Cite
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LncRNA GAS6-AS2 Promotes Non-Small-Cell Lung Cancer Cell Proliferation via Regulating miR-144-3p/ MAPK6 Axis

GAS6-AS2 was identified, and its roles as well as mechanisms in regulating proliferation of non-small cell lung cancer cells were investigated.
[Cell Cycle]
Hou, G., Yang, J., Tang, J., & He, Y. (2021). LncRNA GAS6-AS2 promotes non-small-cell lung cancer cell proliferation via regulating miR-144-3p/ MAPK6 axis. Cell Cycle, 0(0), 1–15. https://doi.org/10.1080/15384101.2020.1867782 Cite
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miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway

Up-regulation of miR-558 alleviated cigarette smoke extract (CSE)-induced damage on HBE cells. The alleviative effect of miR-558 mimic on CSE-induced damage was suppressed by miR-558/TNF receptor superfamily member 1A (TNFRSF1A) overexpression.
[Immunological Investigations]
Jing, X., Luan, Z., & Liu, B. (2021). miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway. Immunological Investigations, 0(0), 1–15. https://doi.org/10.1080/08820139.2021.1874977 Cite
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Secretoglobin 3A2 Eliminates Human Cancer Cells through Pyroptosis

Researchers showed that secretoglobin 3A2 exhibits marked anti-cancer activity against 5 out of 11 of human non-small cell lung cancer cell lines in mouse xenographs, while no effect was observed in 6 of 6 small cell lung cancer cell lines examined.
[Cell Death Discovery]
Yokoyama, S., Nakayama, S., Xu, L., Pilon, A. L., & Kimura, S. (2021). Secretoglobin 3A2 eliminates human cancer cells through pyroptosis. Cell Death Discovery, 7(1), 1–10. https://doi.org/10.1038/s41420-020-00385-w Cite
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Nrf2 Regulates Cell Motility through RhoA–ROCK1 Signaling in Non-Small-Cell Lung Cancer Cells

Researchers observed that nuclear factor-erythroid 2-related factor 2 (Nrf2) suppression following treatment with brusatol in non-small-cell lung cancer cells with either exogenously introduced kelch-like ECH-associated protein 1 or siNrf2 resulted in the inhibition of cell migration and invasion, with shrinking cell morphology due to decreased focal adhesions via inhibition of the RhoA–ROCK1 pathway.
[Scientific Reports]
Ko, E., Kim, D., Min, D. W., Kwon, S.-H., & Lee, J.-Y. (2021). Nrf2 regulates cell motility through RhoA–ROCK1 signalling in non-small-cell lung cancer cells. Scientific Reports, 11(1), 1247. https://doi.org/10.1038/s41598-021-81021-0 Cite
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Modulation of cAMP Metabolism for CFTR Potentiation in Human Airway Epithelial Cells

Human airway epithelial cells were used to test the efficacy of cyclic AMP modulation by ABCC4 and PDE-4 inhibition through a series of concentration–response studies.
[Scientific Reports]
Nguyen, J. P., Bianca, M., Huff, R. D., Tiessen, N., Inman, M. D., & Hirota, J. A. (2021). Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells. Scientific Reports, 11(1), 904. https://doi.org/10.1038/s41598-020-79555-w Cite
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Regulation of Immune Responses by the Airway Epithelial Cell Landscape

The authors discuss how the view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems.
[Nature Reviews Immunology]
Hewitt, R. J., & Lloyd, C. M. (2021). Regulation of immune responses by the airway epithelial cell landscape. Nature Reviews Immunology, 1–16. https://doi.org/10.1038/s41577-020-00477-9 Cite
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Generation of a New Immortalized Human Lung Pericyte Cell Line: A Promising Tool for Human Lung Pericyte Studies

The authors established an immortalized human lung pericyte cell line. Developed using SV40 large T antigen lentivirus, immortalized pericytes exhibited stable SV40T expression, sustained proliferation, and had significantly higher telomerase activity compared to normal human lung pericytes.
[Laboratory Investigation]
Li, P., Wu, Y., Goodwin, A. J., Halushka, P. V., Wilson, C. L., Schnapp, L. M., & Fan, H. (2021). Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Laboratory Investigation, 1–11. https://doi.org/10.1038/s41374-020-00524-y Cite
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Innovent Announces NMPA Acceptance of a Supplemental New Drug Application for TYVYT® (Sintilimab Injection) in Combination with BYVASDA® (Bevacizumab Injection) as First-Line Therapy in Hepatocellular Carcinoma (HCC)

Innovent Biologics, Inc. announced that the National Medical Products Administration (NMPA) of China has accepted the supplemental New Drug Application for TYVYT® in combination with BYVASDA® as first-line therapy for patients with HCC.
[Innovent Biologics, Inc.]
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First Patient Enrolls in PRECISIONS Study for Treatment of Idiopathic Pulmonary Fibrosis

The Pulmonary Fibrosis Foundation announced enrollment of the first patient in PRECISIONS clinical trial. This is the first clinical trial to apply the principles of precision medicine to the treatment of patients with idiopathic pulmonary fibrosis.
[Pulmonary Fibrosis Foundation]
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Overcoming Hypoxia-Induced Resistance of Pancreatic and Lung Tumor Cells by Disrupting the PERK-NRF2-HIF-Axis

Scientists generated human cancer cell lines of pancreatic and lung origin carrying an inducible shRNA against NRF2 and PERK. They report that PERK-related phosphorylation of NRF2 was only critical in Keap1 wildtype cells to escape its degradation, but showed no direct effect on nuclear import or transcriptional activity of NRF2.
[Cell Death & Disease]
Küper, A., Baumann, J., Göpelt, K., Baumann, M., Sänger, C., Metzen, E., Kranz, P., & Brockmeier, U. (2021). Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis. Cell Death & Disease, 12(1), 1–11. https://doi.org/10.1038/s41419-020-03319-7 Cite
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