Achilles Therapeutics Doses First Patient in Phase I/II Study in Advanced Non-Small Cell Lung Cancer

Achilles Therapeutics announced that it has dosed the first patient in a Phase I/II CHIRON study of a clonal neoantigen T cell therapy in patients with advanced non-small cell lung cancer.
[Achilles Therapeutics (GlobeNewswire, Inc.)]
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Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Anti-Fibrotic Activity

Investigators demonstrated that potent and selective ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitors blocked pro-fibrotic responses in a cellular model of idiopathic pulmonary fibrosis, supporting the potential of UCHL1 as a potential therapeutic target in fibrotic diseases.
[Journal of the American Chemical Society]
Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with anti-fibrotic activity | Journal of the American Chemical Society. (n.d.). Retrieved June 25, 2020, from https://pubs.acs.org/doi/10.1021/jacs.0c04527 Cite
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A Synthetic Coumarin Derivative (4-Flourophenylacetamide-Acetyl Coumarin) Impedes Cell Cycle at G0/G1 Stage, Induces Apoptosis, and Inhibits Metastasis via ROS-Mediated p53 and AKT Signaling Pathways in A549 Cells

investigated the mechanism by which 4‐FPAC induced cytotoxicity and arrested the progression of cell cycle as well as metastasis in A549.
[Journal of Biochemical and Molecular Toxicology]
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Vanadium(V/IV)–Transferrin Binding Disrupts the Transferrin Cycle and Reduces Vanadium Uptake and Antiproliferative Activity in Human Lung Cancer Cells

Binding of V(V) or V(IV) to transferrin in cell culture medium drastically reduced its cellular uptake and antiproliferative activity in the A549 cell line that expresses transferrin receptor 1.
[Inorganic Chemistry]
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Copper-Dependent Biological Effects of Particulate Matter Produced by Brake Systems on Lung Alveolar Cells

Researchers studied the cell toxicity of particulate matter produced by different combinations of braking discs and pads containing different amounts of copper.
[Archives of Toxicology]
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Synergistic Effects of Bcl-2 Inhibitors with AZD9291 on Overcoming the Acquired Resistance of AZD9291 in H1975 Cells

Significant upregulation of Bcl-2 was found in AZD9291-resistant H1975 cells compared with H1975, which may constitute an important resistant mechanism of acquired resistance to AZD9291.
[Archives of Toxicology]
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miR-223 Regulates Autophagy Associated with Cisplatin Resistance by Targeting FBXW7 in Human Non-Small Cell Lung Cancer

Investigators found that the level of miR-223 was significantly positively correlated with cisplatin resistance. miR-223 overexpression made NSCLC cells resistant to cisplatin treatment.
[Cancer Cell International]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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