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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Neoadjuvant Nivolumab with or without Relatlimab in Resectable Non-Small-Cell Lung Cancer: A Randomized Phase II Trial
[Nature Medicine] In this ongoing, open-label Phase II study, 60 biomarker-unselected, treatment-naive patients with resectable NSCLC were randomized to receive two preoperative doses of nivolumab with or without relatlimab antibody therapy.
Targeting IL-11 to Reduce Fibrocyte Circulation and Lung Accumulation in Animal Models of Pulmonary Hypertension-Associated Lung Fibrosis
[British Journal of Pharmacology] Human fibrocytes were isolated from peripheral blood of six healthy donors. Recombinant human (rh)-IL-11 and soluble rh-IL-11 receptor, α subunit were used to stimulated fibrocytes in vitro to measure cell migration in a chemotactic migration chamber among other variables.
High Core 1β1,3-Galactosyltransferase 1 Expression Is Associated with Poor Prognosis and Promotes Cellular Radioresistance in Lung Adenocarcinoma
[Journal of Cancer Research and Clinical Oncology] The core 1β1,3-galactosyltransferase 1 (C1GALT1) expression and its clinical relevance were investigated through public databases and lung adenocarcinoma tissue microarray analyses.
Extracellular Vesicles Containing circMYBL1 Induce CD44 in Adenoid Cystic Carcinoma Cells and Pulmonary Endothelial Cells to Promote Lung Metastasis
[Cancer Research] Researchers identified a circRNA derived from MYBL1 pre-mRNA that accompanied overexpression of MYBL1 in adenoid cystic carcinoma (ACC). Overexpression of circMYBL1 was correlated with increased lung metastasis and poor overall survival in ACC patients.
Development of m6A/m5C/m1A Regulated lncRNA Signature for Prognostic Prediction, Personalized Immune Intervention, and Drug Selection in LUAD
[Journal of Cellular and Molecular Medicine] The authors focused on 33 genes that were regulated by m6A, m5C, or m1A (mRG), which were used to form mRG clusters and clusters of mRG differentially expressed genes clusters.
Burn Pit Smoke Condensate-Mediated Toxicity in Human Airway Epithelial Cells
[Chemical Research In Toxicology] Scientists explored the effects of burn pit smoke condensates on human airway epithelial cells (HAECs) to understand their impact on cellular targets in the human lung. HAECs were cultured at the air–liquid interface and exposed to burn pit waste smoke condensates.
Lytic Bacteriophages Induce the Secretion of Antiviral and Proinflammatory Cytokines from Human Respiratory Epithelial Cells
[PLOS Biology] Using a panel of Pseudomonas aeruginosa phages and human airway epithelial cells derived from a person with cystic fibrosis, the authors determined that interactions between phages and epithelial cells depend on specific phage properties as well as physiochemical features of the microenvironment.
Interstitial Lung Disease
[Jama-Journal Of The American Medical Association] Interstitial lung disease consists of a group of pulmonary disorders characterized by inflammation and/or fibrosis of the lung parenchyma associated with progressive dyspnea that frequently results in end-stage respiratory failure.
FDA Approves Genentech’s Alecensa as First Adjuvant Treatment for People with ALK-Positive Early-Stage Lung Cancer
[Genentech] Genentech, announced that the US FDA has approved Alecensa® for adjuvant treatment following tumor resection for patients with anaplastic lymphoma kinase (ALK)-positive NSCLC, as detected by an FDA-approved test.
Jagged2 Targeting in Lung Cancer Activates Anti-Tumor Immunity via Notch-Induced Functional Reprogramming of Tumor-Associated Macrophages
[Immunity] The authors studied the role of the Notch ligand Jagged2 on immune evasion in NSCLC. Higher expression of JAG2 in NSCLC negatively correlated with survival.
Discovery of Gefitinib-1,2, 3-Triazole Derivatives against Lung Cancer via Inducing Apoptosis and Inhibiting the Colony Formation
[Scientific Reports] A series of 20 novel gefitinib derivatives incorporating the 1,2,3-triazole moiety were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against epidermal growth factor receptor wild-type human NSCLC cells and human lung adenocarcinoma cells as NSCLC.
Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by Increasing ODC1 to Suppress Autophagy
[Journal Of Proteome Research] Investigators found that pirin was upregulated in NSCLC, and its expression was positively correlated with poor prognosis. Overexpression of pirin inhibited autophagy and promoted NSCLC proliferation.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
