AKT

[Cell Death & Disease] The authors reported that hypoxia-inducible factor 1α (HIF-1α) was upregulated after ATP treatment and mediated the ATP-driven chemoresistance process.

[Cell Death & Disease] Researchers reported that expression of mucin 15 (MUC15) was downregulated in liver tumor-initiating cells, chemoresistance, and recurrent HCC samples.

[Phytotherapy Research] Investigators explored the function of lucidone in tumor cytotoxicity and chemosensitivity through the suppression of receptor for advanced glycation end products-initiated signaling in pancreatic ductal adenocarcinoma cells.

[Acta Pharmacologica Sinica] The authors investigated the effects of TMZ on myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice.

[Journal of Mammary Gland Biology and Neoplasia] Investigators found that chronic leptin treatment induced a switch from an epithelial to a mesenchymal morphology, partial loss of E-cadherin and gain of vimentin expression.

[Leukemia] Secondary transplantation from PDX and ΔPTEN models of T-cell acute lymphoblastic leukemia (T-ALL), confirmed delayed leukemia development and extended survival of mice engrafted with T-ALL from ARV-825 treated mice, providing functional confirmation of depletion of leukemia-initiating cells.