AKT

[Cell Death & Disease] The inhibitory effect of Selenoprotein S (SelS) on hepatic steatosis and insulin resistance was confirmed by SelS overexpression in primary hepatocytes in vitro.

[BMC Cancer] The bioactivities of inhibitors on PTEN adequate Huh7 and deficient Mahlavu cells were investigated with real time cell growth, cell cycle and cell migration assays.

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.

[Cell Death & Disease] Scientists detected the receptor tyrosine kinase activity in gefitinib-resistant colorectal cancer cells, pan-erb-b2 receptor tyrosine kinase 3 (ErbB3)/EGFR was significantly activated and provided a potential multi-ErbB treatment target.

[Science Advances] Researchers uncovered that the depletion of ARAF promoted anchorage-independent growth and metastasis through activation of AKT signaling in a subset of lung cancer cells.

[Science Signaling] The authors found that glucocorticoid receptor was present in cytoplasmic KRAS-containing complexes and inhibited the activation of wild-type and oncogenic KRAS in mouse embryonic fibroblasts and human lung cancer A549 cells.