AKT

[Biochemical and Biophysical Research Communications] The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.

[Scientific Reports] In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.

[Oncogenesis] The authors identified that guanylate-binding protein (GBP)1 and GBP2 interacted with MCL-1, the key prosurvival member of the BCL-2 family, via its BH3 domain. GBPs induced caspase-dependent apoptosis in chronic myeloid leukemia and acute myeloid leukemia cells, where the proapoptotic BCL-2 member, BAK, was an indispensable mediator.

[Chemical Biology & Drug Design] The authors determined the efficacy of pyronaridine in four different NSCLC cell lines and explored its mechanism in H1975.

[Anti-Cancer Agents in Medicinal Chemistry] The authors identified five candidate genes, including ESM1，CXCR4，JAG1，FLT1 and PTK2 and two pathways, including Rap1 signaling pathway and PI3K-Akt signaling pathway in vascular endothelial cells that differentiate into tip cells and stalk cells using bioinformatic analysis.

[Scientific Reports] Investigators compared the therapeutic potential of a novel drug candidate, NTG-101 to MSCs, including rat cartilage derived stem cells, bone marrow stem cells and human umbilical cord derived MSCs for the treatment of Degenerative Disc Disease.