Tag Archives: AMPK

FGF21 Promotes Ischemic Angiogenesis and Endothelial Progenitor Cells Function under Diabetic Conditions in an AMPK/NAD+-Dependent Manner

The in vivo results showed that FGF21 efficiently improved blood perfusion and ischaemic angiogenesis in both type 1 and type 2 diabetic mice, and these effects were accompanied by enhanced endothelial progenitor cells mobilization and infiltration into ischemic muscle tissues and increases in plasma stromal cell–derived factor‐1 concentration.
[Journal of Cellular and Molecular Medicine]
Dai, Q., Fan, X., Meng, X., Sun, S., Su, Y., Ling, X., Chen, X., Wang, K., Dai, X., Zhang, C., Da, S., Zhang, G., Gu, C., Chen, H., He, J., Hu, H., Yu, L., Pan, X., Tan, Y., & Yan, X. (n.d.). FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16369 Cite
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Cordycepin Ameliorates Nonalcoholic Steatohepatitis via Activation of AMP‐Activated Protein Kinase Signaling Pathway

Researchers evaluated the effects of cordycepin on lipid storage in hepatocytes, inflammation, and fibrosis development in mice with nonalcoholic steatohepatitis.
[Hepatology]
Lan, T., Yu, Y., Zhang, J., Li, H., Weng, Q., Jiang, S., Tian, S., Xu, T., Hu, S., Yang, G., Zhang, Y., Wang, W., Wang, L., Zhu, Q., Rong, X., & Guo, J. (n.d.). Cordycepin Ameliorates Nonalcoholic Steatohepatitis via Activation of AMP-Activated Protein Kinase Signaling Pathway. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31749 Cite
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HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
[Cancer Research]
Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., Jiao, Q., Wang, Y., Du, L., Zhou, F., Jiang, Y., Chen, F., Wang, C., Tang, B., & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3044 Cite
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Autophagy Inhibitors Increase the Susceptibility of KRAS-Mutant Human Colorectal Cancer Cells to a Combined Treatment of 2-deoxy-D-glucose and Lovastatin

A combination of lovastatin and 2-deoxy-D-glucose synergistically reduced cell viability, arrested cells in the G2/M phase, and induced apoptosis. The combined treatment also reduced cellular oxygen consumption and extracellular acidification rate, resulting in decreased production of ATP and lower steady-state ATP levels.
[Acta Pharmacologica Sinica]
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Alpha-Enolase (ENO1), Identified as an Antigen to Monoclonal Antibody 12C7, Promotes the Self-Renewal and Malignant Phenotype of Lung Cancer Stem Cells by AMPK/mTOR Pathway

Immunofluorescence was used for antigen localization. After targeted antigen purification by electrophoresis and immunoblot, the antigen was identified by LC-MALDI-TOF/TOF mass spectrometry, immunofluorescence, and immunoprecipitation.
[Stem Cell Research & Therapy]
Shu, X., Cao, K.-Y., Liu, H.-Q., Yu, L., Sun, L.-X., Yang, Z.-H., Wu, C.-A., & Ran, Y.-L. (2021). Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway. Stem Cell Research & Therapy, 12(1), 119. https://doi.org/10.1186/s13287-021-02160-9 Cite
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Exosomal LINC00174 Derived from Vascular Endothelial Cells Attenuates Myocardial Ischemia-Reperfusion Injury via p53-Mediated Autophagy and Apoptosis

The authors investigated the regulation of specific long non-coding RNAs on the progression of ischemia/reperfusion injury. They identified and characterized the exosomes derived from mouse primary aortic endothelial cells.
[Molecular Therapy-Nucleic Acids]
Su, Q., Lv, X.-W., Xu, Y.-L., Cai, R.-P., Dai, R.-X., Yang, X.-H., Zhao, W.-K., & Kong, B.-H. (2021). Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial Ischemia-Reperfusion Injury via p53-mediated autophagy and apoptosis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.005 Cite
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Withaferin A Alleviates Fulminant Hepatitis by Targeting Macrophage and NLRP3

Researchers evaluated the hepatoprotective role and mechanism of Withaferin A in D-galactosamine/lipopolysaccharide-induced fulminant hepatitis.
[Cell Death & Disease]
Xia, Y., Wang, P., Yan, N., Gonzalez, F. J., & Yan, T. (2021). Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell Death & Disease, 12(2), 1–14. https://doi.org/10.1038/s41419-020-03243-w Cite
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Inhibition of CAMKK2 Impairs Autophagy and Castration-Resistant Prostate Cancer via Suppression of AMPK-ULK1 Signaling

Scientists used molecular, genetic, and pharmacological approaches to elucidate an androgen receptor-mediated autophagy cascade involving Ca2+/calmodulin-dependent protein kinase kinase 2 (CAMKK2), 5’-AMP-activated protein kinase (AMPK), and Unc-51 like autophagy activating kinase 1 (ULK1), but independent of canonical mechanistic target of rapamycin activity.
[Oncogene]
Lin, C., Blessing, A. M., Pulliam, T. L., Shi, Y., Wilkenfeld, S. R., Han, J. J., Murray, M. M., Pham, A. H., Duong, K., Brun, S. N., Shaw, R. J., Ittmann, M. M., & Frigo, D. E. (2021). Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01658-z Cite
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Molecular Profiling of Epigenetic Landscape of Cancer Cells during Extracellular Matrix Detachment

Researchers showed both EZH2 expression and its enzymatic activity were significantly increased in ECM detached cancer cells when compared to the attached cells. Inhibition of EZH2 resulted in a significant reduction in cell proliferation, spheroids size, and induction in apoptosis in ECM detached cells.
[Scientific Reports]
Khan, M. I., Zamzami, M. A., Ahmad, A., & Choudhry, H. (2021). Molecular profiling of epigenetic landscape of cancer cells during extracellular matrix detachment. Scientific Reports, 11(1), 2784. https://doi.org/10.1038/s41598-021-82431-w Cite
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A GLP-1 Analog Lowers ER Stress and Enhances Protein Folding to Ameliorate Homocysteine-Induced Endothelial Dysfunction

Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase, an important endothelial reticulum chaperone in endothelial cells, and this effect was mediated by AMPK activation.
[Acta Pharmacologica Sinica]
Cheng, C. K., Luo, J.-Y., Lau, C. W., Cho, W. C., Ng, C. F., Ma, R. C. W., Tian, X. Y., & Huang, Y. (2021). A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-020-00589-x Cite
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Targeting TRPV1-Mediated Autophagy Attenuates Nitrogen Mustard-Induced Dermal Toxicity

Scientists confirmed that nitrogen mustard (NM) dose-dependently caused cell death and induced autophagy in keratinocytes. Suppression of autophagy by 3-methyladenine, chloroquine, and bafilomycin A1 or ATG5 siRNA attenuated NM-induced keratinocyte cell death.
[Signal Transduction and Targeted Therapy]
Chen, M., Dong, X., Deng, H., Ye, F., Zhao, Y., Cheng, J., Dan, G., Zhao, J., Sai, Y., Bian, X., & Zou, Z. (2021). Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-020-00389-z Cite
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