Tag Archives: AMPK

Nkx2‐3 Induces Autophagy Inhibiting Proliferation and Migration of Vascular Smooth Muscle Cells via AMPK/mTOR Signaling Pathway

Investigators used carotid balloon injury model and platelet‐derived growth factor‐BB‐treated vascular smooth muscle cells as in vivo and in vitro experimental models.
[Journal of Cellular Physiology]
Zheng, H., Zhai, W., Zhong, C., Hong, Q., Li, H., Rui, B., Zhu, X., Que, D., Feng, L., Yu, B., Huang, G., Yin, J., Li, J., Yan, J., & Yang, P. (n.d.). Nkx2-3 induces autophagy inhibiting proliferation and migration of vascular smooth muscle cells via AMPK/mTOR signaling pathway. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30400 Cite
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Valdecoxib Improves Lipid-Induced Skeletal Muscle Insulin Resistance via Simultaneous Suppression of Inflammation and Endoplasmic Reticulum Stress

Scientists suggest that valdecoxib alleviated insulin resistance through AMP-activated protein kinase/heat shock protein beta 1-mediated inhibition of inflammation and endoplasmic reticulum stress in skeletal muscle under hyperlipidemic conditions.
[Biochemical Pharmacology]
AbstractGraphical Abstract
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Ferritinophagy Is Involved in the Zinc Oxide Nanoparticles-Induced Ferroptosis of Vascular Endothelial Cells

Scientists report that zinc oxide nanoparticles can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner.
[Autophagy]
Qin, X., Zhang, J., Wang, B., Xu, G., Yang, X., Zou, Z., & Yu, C. (2021). Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy, 0(0), 1–20. https://doi.org/10.1080/15548627.2021.1911016 Cite
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AMPK Activation by ASP4132 Inhibits Non-small Cell Lung Cancer Cell Growth

In primary NSCLC cells and established cell lines ASP4132 potently inhibited cell growth, proliferation and cell cycle progression as well as cell migration and invasion.
[Cell Death & Disease]
Xia, Y., Zha, J., Sang, Y.-H., Yin, H., Xu, G., Zhen, J., Zhang, Y., & Yu, B. (2021). AMPK activation by ASP4132 inhibits non-small cell lung cancer cell growth. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03655-2 Cite
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Platelet Autophagic Machinery Involved in Thrombosis through a Novel Linkage of AMPK-MTOR to Sphingolipid Metabolism

The authors revealed that LC3-II formation and SQSTM1/p62 degradation were noted in H2O2-activated human platelets, which could be blocked by 3-methyladenine and bafilomycin A1, indicating that platelet activation may cause platelet autophagy.
[Autophagy]
Lee, T.-Y., Lu, W.-J., Changou, C. A., Hsiung, Y.-C., Trang, N. T. T., Lee, C.-Y., Chang, T.-H., Jayakumar, T., Hsieh, C.-Y., Yang, C.-H., Chang, C.-C., Chen, R.-J., Sheu, J.-R., & Lin, K.-H. (2021). Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. Autophagy, 0(0), 1–18. https://doi.org/10.1080/15548627.2021.1904495 Cite
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IL37 Overexpression Inhibits Autophagy and Apoptosis Induced by Hepatic Ischemia Reperfusion Injury via Modulating AMPK/mTOR/ULLK1 Signaling Pathways

Scientists investigated the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism.
[Life Sciences]
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Macropinocytosis in Cancer-Associated Fibroblasts is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness

Investigators provided evidence that macropinocytosis was operational in the pancreatic tumor stroma. They found that glutamine deficiency triggered macropinocytic uptake in pancreatic cancer-associated fibroblasts.
[Cancer Discovery]
Zhang, Y., Recouvreux, M. V., Jung, M., Galenkamp, K. M. O., Li, Y., Zagnitko, O., Scott, D. A., Lowy, A. M., & Commisso, C. (2021). Macropinocytosis in Cancer-Associated Fibroblasts is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0119 Cite
AbstractPress Release
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Estrogen Plays a Crucial Role in Rab9‐Dependent Mitochondrial Autophagy, Delaying Arterial Senescence

Researchers showed that E2‐induced mitochondrial autophagy played a crucial role in the delay of vascular senescence.
[Journal of the American Heart Association]
Sasaki Yuichi, Ikeda Yoshiyuki, Uchikado Yoshihiro, Akasaki Yuichi, Sadoshima Junichi, & Ohishi Mitsuru. (n.d.). Estrogen Plays a Crucial Role in Rab9‐Dependent Mitochondrial Autophagy, Delaying Arterial Senescence. Journal of the American Heart Association, 0(0), e019310. https://doi.org/10.1161/JAHA.120.019310 Cite
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WW Domain-Binding Protein 2 Overexpression Prevents Diet-Induced Liver Steatosis and Insulin Resistance through AMPKβ1

In vitro experiments showed that in the human normal hepatocyte cell line LO2 and primary hepatocytes isolated from mice, overexpression of WBP2 reduced fat deposition, and knocking out or knocking down WBP2 aggravated PA-induced fat deposition.
[Cell Death & Disease]
Zheng, Z., Li, Y., Fan, S., An, J., Luo, X., Liang, M., Zhu, F., & Huang, K. (2021). WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1. Cell Death & Disease, 12(3), 1–16. https://doi.org/10.1038/s41419-021-03536-8 Cite
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Impact of Hypoxia and Ampk on Cftr-Mediated Bicarbonate Secretion in Human Cholangiocyte Organoids

Scientists investigated the effect of hypoxia on cystic fibrosis transmembrane conductance regulator activity in intrahepatic cholangiocyte organoids and test drug-interventions to restore bicarbonate secretion.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Roos, F. J. M., Bijvelds, M. J. C., Verstegen, M. M. A., Roest, H. P., Metselaar, H. J., Polak, W. G., Jonge, H. R. de, IJzermans, J. N. M., & Laan, L. J. W. van der. (2021). Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00389.2020 Cite
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FGF21 Promotes Ischemic Angiogenesis and Endothelial Progenitor Cells Function under Diabetic Conditions in an AMPK/NAD+-Dependent Manner

The in vivo results showed that FGF21 efficiently improved blood perfusion and ischaemic angiogenesis in both type 1 and type 2 diabetic mice, and these effects were accompanied by enhanced endothelial progenitor cells mobilization and infiltration into ischemic muscle tissues and increases in plasma stromal cell–derived factor‐1 concentration.
[Journal of Cellular and Molecular Medicine]
Dai, Q., Fan, X., Meng, X., Sun, S., Su, Y., Ling, X., Chen, X., Wang, K., Dai, X., Zhang, C., Da, S., Zhang, G., Gu, C., Chen, H., He, J., Hu, H., Yu, L., Pan, X., Tan, Y., & Yan, X. (n.d.). FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16369 Cite
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