The in vivo results showed that FGF21 efficiently improved blood perfusion and ischaemic angiogenesis in both type 1 and type 2 diabetic mice, and these effects were accompanied by enhanced endothelial progenitor cells mobilization and infiltration into ischemic muscle tissues and increases in plasma stromal cell–derived factor‐1 concentration.
[Journal of Cellular and Molecular Medicine]
Dai, Q., Fan, X., Meng, X., Sun, S., Su, Y., Ling, X., Chen, X., Wang, K., Dai, X., Zhang, C., Da, S., Zhang, G., Gu, C., Chen, H., He, J., Hu, H., Yu, L., Pan, X., Tan, Y., & Yan, X. (n.d.). FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16369 Cite
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