Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Investigators showed that berberine administration markedly ameliorated intralipid-induced insulin resistance without affecting blood glucose. They used human skeletal muscle cells, hepatocytes, human umbilical vein endothelial cells, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Neohesperidin Enhances PGC-1α-Mediated Mitochondrial Biogenesis and Alleviates Hepatic Steatosis in High Fat Diet Fed Mice

Neohesperidin (NHP) elevated hepatic mitochondrial biogenesis and fatty acid oxidation by increasing PGC-1α expression. The activation of AMP-activated protein kinase was involved in NHP induced PGC-1α expression.
[FASEB Journal]
Wang, S., Sheng, H., Bai, Y., Weng, Y., Fan, X., Lou, L., & Zhang, F. (2020). Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice. Nutrition & Diabetes, 10(1), 1–11. https://doi.org/10.1038/s41387-020-00130-3 Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Metformin Inhibits Pancreatic Cancer Metastasis Caused by SMAD4 Deficiency and Consequent HNF4G Upregulation

The authors found that metformin suppressed HNF4G activity via AMPK-mediated phosphorylation-coupled ubiquitination degradation and inhibited in vitro invasion and in vivo metastasis of pancreatic ductal adenocarcinoma cells with SMAD4 deficiency.
[Protein & Cell]
Wang, C., Zhang, T., Liao, Q., Dai, M., Guo, J., Yang, X., Tan, W., Lin, D., Wu, C., & Zhao, Y. (2020). Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation. Protein & Cell. https://doi.org/10.1007/s13238-020-00760-4 Cite
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AMPK Activator C24 Inhibits Hepatic Lipogenesis and Ameliorates Dyslipidemia in HFHC Diet-Induced Animal Models

Researchers showed that C24 dose-dependently increased the phosphorylation of AMPKα and acetyl-CoA carboxylase, and inhibited lipogenesis in HepG2 cells.
[Acta Pharmacologica Sinica]
Sun, S., Xie, Z., Zhang, Y., Zhang, X., Zhou, C., Yin, J., Yu, Y., Cui, S., Jiang, H., Li, T., Li, J., Nan, F., & Li, J. (2020). AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models. Acta Pharmacologica Sinica, 1–8. https://doi.org/10.1038/s41401-020-0472-9 Cite
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Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

Fibrosis, or the accumulation of ECM, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, scientists cross-examined human primary cells from various tissues treated with TGF-β, as well as kidney and liver fibrosis models.
[Cell Reports Medicine]
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The Influence of Hypoxia and Energy Depletion on the Response of Endothelial Cells to the Vascular Disrupting Agent Combretastatin A-4-Phosphate

Scientists found that active RhoA and ROCK effector phospho-myosin light chain (pMLC) were downregulated in endothelial cells by severe hypoxia. CA4P failed to activate RhoA/ROCK/pMLC but its activity was restored upon reoxygenation.
[Scientific Reports]
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