The authors observed altered interactions between coactivator-associated arginine methyltransferase 1 (CARM1) and AMP-activated protein kinase (AMPK) and its network, including forkhead box protein O1, during muscle disuse.
Investigators showed that the level of the amino acid serine in the cytosol affects the migratory properties of lung adenocarcinoma cells.
[Cell Death & Disease]
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Bouzidi, A., Magnifico, M. C., Paiardini, A., Macone, A., Boumis, G., Giardina, G., Rinaldo, S., Liberati, F. R., Lauro, C., Limatola, C., Lanzillotta, C., Tramutola, A., Perluigi, M., Sgarbi, G., Solaini, G., Baracca, A., Paone, A., & Cutruzzolà, F. (2020). Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity. Cell Death & Disease, 11(11), 1–14. https://doi.org/10.1038/s41419-020-03215-0 Cite
The authors investigated the molecular effects of physiologically attainable concentration of curcumin in the intestinal lumen on mechanistic target of rapamycin complex 1 signaling in Caco-2 cells.
Researchers showed that compared to expression in adjacent non‐cancerous tissues, RHOF was frequently upregulated in hepatocellular carcinoma tumor samples and elevated under conditions of glucose deprivation.
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Scientists consolidate current literature, including their recent work, while evaluating how ubiquitin-dependent mitophagy is regulated both in muscle and non-muscle cells through the steps of mitochondrial fission, ubiquitylation and autophagosomal engulfment.
[Frontiers in Physiology]
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Researchers discovered a small-molecule compound, which they named tryptolinamide, that activated mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs.
[Nature Chemical Biology]
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Kobayashi, H., Hatakeyama, H., Nishimura, H., Yokota, M., Suzuki, S., Tomabechi, Y., Shirouzu, M., Osada, H., Mimaki, M., Goto, Y., & Yoshida, M. (2020). Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations. Nature Chemical Biology, 1–9. https://doi.org/10.1038/s41589-020-00676-4 Cite
Scientists showed that acetylsalicylic acid and salicylic acid present anticancer effects against a murine model of implanted melanoma. These effects were also validated in 3D- and 2D-cultured melanoma B16F10 cells, where the drugs promoted pro-apoptotic effects.
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Ausina, P., Branco, J. R., Demaria, T. M., Esteves, A. M., Leandro, J. G. B., Ochioni, A. C., Mendonça, A. P. M., Palhano, F. L., Oliveira, M. F., Abou-Kheir, W., Sola-Penna, M., & Zancan, P. (2020). Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis. Scientific Reports, 10(1), 19617. https://doi.org/10.1038/s41598-020-76824-6 Cite
Scientists observed that cluster differentiation 44 standard isoform (CD44s) was responsible for caspase-1/IL1B activation both in hepatocellular carcinoma (HCC) tissues and five HCC cell lines. In normoxia conditions, CD44s knockdown repressed the activation of caspase-1/IL1B via stimulating AMPK-mediated autophagy.
[Cell Death & Disease]
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Researchers developed and characterized the efficacy of novel AMPK activator that selectively induced oxidative phosphorylation and decreased glycolysis in TNBC cells, while not affecting these pathways in normal cells.
[British Journal of Cancer]
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Tailor, D., Going, C. C., Resendez, A., Kumar, V., Nambiar, D. K., Li, Y., Dheeraj, A., LaGory, E. L., Ghoochani, A., Birk, A. M., Stoyanova, T., Ye, J., Giaccia, A. J., Le, Q.-T., Singh, R. P., Sledge, G. W., Pitteri, S. J., & Malhotra, S. V. (2020). Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01137-4 Cite
Coactivator-associated arginine methyltransferase 1 (CARM1) skeletal muscle-specific knockout mice displayed reduced muscle mass and dysregulated autophagic and atrophic processes downstream of AMP-activated protein kinase (AMPK).
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By using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, researchers identified a branched-chain amino acid aminotransferase 2 as a novel suppressor of ferroptosis.
[Cell Death & Differentiation]
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Wang, K., Zhang, Z., Tsai, H., Liu, Y., Gao, J., Wang, M., Song, L., Cao, X., Xu, Z., Chen, H., Gong, A., Wang, D., Cheng, F., & Zhu, H. (2020). Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00644-4 Cite