The in vivo results showed that FGF21 efficiently improved blood perfusion and ischaemic angiogenesis in both type 1 and type 2 diabetic mice, and these effects were accompanied by enhanced endothelial progenitor cells mobilization and infiltration into ischemic muscle tissues and increases in plasma stromal cell–derived factor‐1 concentration.
[Journal of Cellular and Molecular Medicine]
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Dai, Q., Fan, X., Meng, X., Sun, S., Su, Y., Ling, X., Chen, X., Wang, K., Dai, X., Zhang, C., Da, S., Zhang, G., Gu, C., Chen, H., He, J., Hu, H., Yu, L., Pan, X., Tan, Y., & Yan, X. (n.d.). FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16369 Cite
Researchers evaluated the effects of cordycepin on lipid storage in hepatocytes, inflammation, and fibrosis development in mice with nonalcoholic steatohepatitis.
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Lan, T., Yu, Y., Zhang, J., Li, H., Weng, Q., Jiang, S., Tian, S., Xu, T., Hu, S., Yang, G., Zhang, Y., Wang, W., Wang, L., Zhu, Q., Rong, X., & Guo, J. (n.d.). Cordycepin Ameliorates Nonalcoholic Steatohepatitis via Activation of AMP-Activated Protein Kinase Signaling Pathway. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31749 Cite
Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
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Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., Jiao, Q., Wang, Y., Du, L., Zhou, F., Jiang, Y., Chen, F., Wang, C., Tang, B., & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3044 Cite
A combination of lovastatin and 2-deoxy-D-glucose synergistically reduced cell viability, arrested cells in the G2/M phase, and induced apoptosis. The combined treatment also reduced cellular oxygen consumption and extracellular acidification rate, resulting in decreased production of ATP and lower steady-state ATP levels.
[Acta Pharmacologica Sinica]
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Immunofluorescence was used for antigen localization. After targeted antigen purification by electrophoresis and immunoblot, the antigen was identified by LC-MALDI-TOF/TOF mass spectrometry, immunofluorescence, and immunoprecipitation.
[Stem Cell Research & Therapy]
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Shu, X., Cao, K.-Y., Liu, H.-Q., Yu, L., Sun, L.-X., Yang, Z.-H., Wu, C.-A., & Ran, Y.-L. (2021). Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway. Stem Cell Research & Therapy, 12(1), 119. https://doi.org/10.1186/s13287-021-02160-9 Cite
The authors investigated the regulation of specific long non-coding RNAs on the progression of ischemia/reperfusion injury. They identified and characterized the exosomes derived from mouse primary aortic endothelial cells.
[Molecular Therapy-Nucleic Acids]
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Su, Q., Lv, X.-W., Xu, Y.-L., Cai, R.-P., Dai, R.-X., Yang, X.-H., Zhao, W.-K., & Kong, B.-H. (2021). Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial Ischemia-Reperfusion Injury via p53-mediated autophagy and apoptosis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.005 Cite
Researchers evaluated the hepatoprotective role and mechanism of Withaferin A in D-galactosamine/lipopolysaccharide-induced fulminant hepatitis.
[Cell Death & Disease]
Scientists used molecular, genetic, and pharmacological approaches to elucidate an androgen receptor-mediated autophagy cascade involving Ca2+/calmodulin-dependent protein kinase kinase 2 (CAMKK2), 5’-AMP-activated protein kinase (AMPK), and Unc-51 like autophagy activating kinase 1 (ULK1), but independent of canonical mechanistic target of rapamycin activity.
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Lin, C., Blessing, A. M., Pulliam, T. L., Shi, Y., Wilkenfeld, S. R., Han, J. J., Murray, M. M., Pham, A. H., Duong, K., Brun, S. N., Shaw, R. J., Ittmann, M. M., & Frigo, D. E. (2021). Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01658-z Cite
Researchers showed both EZH2 expression and its enzymatic activity were significantly increased in ECM detached cancer cells when compared to the attached cells. Inhibition of EZH2 resulted in a significant reduction in cell proliferation, spheroids size, and induction in apoptosis in ECM detached cells.
Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase, an important endothelial reticulum chaperone in endothelial cells, and this effect was mediated by AMPK activation.
[Acta Pharmacologica Sinica]
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Cheng, C. K., Luo, J.-Y., Lau, C. W., Cho, W. C., Ng, C. F., Ma, R. C. W., Tian, X. Y., & Huang, Y. (2021). A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-020-00589-x Cite
Scientists confirmed that nitrogen mustard (NM) dose-dependently caused cell death and induced autophagy in keratinocytes. Suppression of autophagy by 3-methyladenine, chloroquine, and bafilomycin A1 or ATG5 siRNA attenuated NM-induced keratinocyte cell death.
[Signal Transduction and Targeted Therapy]
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Chen, M., Dong, X., Deng, H., Ye, F., Zhao, Y., Cheng, J., Dan, G., Zhao, J., Sai, Y., Bian, X., & Zou, Z. (2021). Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-020-00389-z Cite