AMPK

[Journal of Hepatology] Investigators undertook molecular and functional studies to interrogate the significance of the myeloid Ikaros–SIRT1 axis in the innate immune activation and to determine whether it served as a homeostatic sentinel in hepatic rejuvenation in mouse and human liver.

[Acta Pharmacologica Sinica] Investigators demonstrated that organic anion transporting polypeptide and endocytosis synergistically drove the uptake of the farnesylthiosalicylic acid-IR783 conjugate in breast cancer MDA-MB-231 cells, resulting in superior tumor-targeting ability of the conjugate both in vitro and in vivo.

[Cell Reports] Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.

[Life Sciences] RNA sequencing of liver tissue showed that the expression of SCD1 increased significantly in chronic periodontitis rats compared to controls. KEGG enrichment analysis showed that the AMPK signalling pathway may have been involved in liver steatosis.

[Experimental Cell Research] Researchers investigated the effects of Ad-apoptin on glycolysis, migration and invasion of non-small cell lung cancer.

[Archives of Pharmacal Research] Researchers evaluated the anticancer effect of ACY-241, an HDAC6-selective inhibitor, on erlotinib-resistant pancreatic cancer cells that overexpressed HDAC6.