AMPK

[Cell Death & Disease] Circ_0057558 acted as a miR-206 sponge to de-repress the ROCK1/AMPK signaling and facilitated lipogenesis and triglyceride secretion, which greatly contributed to nonalcoholic fatty liver disease development and progression.

[Cell Reports] Liver cells with disordered tyrosine catabolism, as exemplified by the suppression of a tyrosine catabolic enzyme 4-hydroxyphenylpyruvate dioxygenase (HPD), displayed augmented tumorigenic and proliferative potentials.

[Communications Biology] Scientists showed a xanthene derivative, DS20060511, induced GLUT4 translocation to the skeletal muscle cell surface, thereby stimulating glucose uptake into the tissue.

[Acta Pharmacologica Sinica] Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.

[Cancer Cell International] Scientists explored the mechanism involved in metformin-mediated inhibition of AR-negative prostate cancer.

[FASEB Journal] Researchers found that specific inhibition of MyD88 reduces the activation of canonical nuclear factor-kappa pathway and expression of receptors for inflammatory cytokines in denervated muscle.