Loss of Tyrosine Catabolic Enzyme HPD Promotes Glutamine Anaplerosis through mTOR Signaling in Liver Cancer

Liver cells with disordered tyrosine catabolism, as exemplified by the suppression of a tyrosine catabolic enzyme 4-hydroxyphenylpyruvate dioxygenase (HPD), displayed augmented tumorigenic and proliferative potentials.