ATP-binding cassette

[Cell Death Discovery] Researchers found that the expression of ABCA8, a member of ABCA subfamily transporters, was significantly increased in human pancreatic cancer (PC) cells after gemcitabine (GEM) treatment, as well as in established GEM-resistant PC cells.

[Histochemistry and Cell Biology] The authors demonstrated the capacity of human hair follicles for cholesterol transport and trafficking.

[Cells] The transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-2B prostate cancer cells were compared for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation. Next-Gen sequencing detected 9409 and 7757 genes differentially expressed in LNCaP and C4-2B cells, compared to their parental counterparts.

[Chemico-Biological interactions] Researchers established CPT11-resistant variants of three human colon cancer cell lines, and found that gain of the resistance elicited an up-regulation of aldo-keto reductase 1C3 in the cells.

[Archives of Toxicology] The authors concluded that MRP1 protected placental cells from methyl mercury-induced oxidative stress by exporting the toxic metal and by maintaining the placental cells' glutathione status in equilibrium.

[Life Sciences] Primary amniotic mesenchymal cells (AMCs), chorion cells and decidual cells were isolated from placental membranes of women with uncomplicated pregnancies at full-term using enzymatic digestion.