Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle

0
20
The authors demonstrated the capacity of human hair follicles for cholesterol transport and trafficking.
[Histochemistry and Cell Biology]
6807162 {6807162:K94XVGJI} 1 apa 50 default 1 157700 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22K94XVGJI%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Palmer%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPalmer%2C%20M.%20A.%2C%20Smart%2C%20E.%2C%20%26amp%3B%20Haslam%2C%20I.%20S.%20%282021%29.%20Localisation%20and%20regulation%20of%20cholesterol%20transporters%20in%20the%20human%20hair%20follicle%3A%20mapping%20changes%20across%20the%20hair%20cycle.%20%26lt%3Bi%26gt%3BHistochemistry%20and%20Cell%20Biology%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00418-020-01957-8%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00418-020-01957-8%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3Ba%20title%3D%26%23039%3BCite%20in%20RIS%20Format%26%23039%3B%20class%3D%26%23039%3Bzp-CiteRIS%26%23039%3B%20data-zp-cite%3D%26%23039%3Bapi_user_id%3D6807162%26amp%3Bitem_key%3DK94XVGJI%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BCite%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Localisation%20and%20regulation%20of%20cholesterol%20transporters%20in%20the%20human%20hair%20follicle%3A%20mapping%20changes%20across%20the%20hair%20cycle%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megan%20A.%22%2C%22lastName%22%3A%22Palmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eleanor%22%2C%22lastName%22%3A%22Smart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iain%20S.%22%2C%22lastName%22%3A%22Haslam%22%7D%5D%2C%22abstractNote%22%3A%22Cholesterol%20has%20long%20been%20suspected%20of%20influencing%20hair%20biology%2C%20with%20dysregulated%20homeostasis%20implicated%20in%20several%20disorders%20of%20hair%20growth%20and%20cycling.%20Cholesterol%20transport%20proteins%20play%20a%20vital%20role%20in%20the%20control%20of%20cellular%20cholesterol%20levels%20and%20compartmentalisation.%20This%20research%20aimed%20to%20determine%20the%20cellular%20localisation%2C%20transport%20capability%20and%20regulatory%20control%20of%20cholesterol%20transport%20proteins%20across%20the%20hair%20cycle.%20Immunofluorescence%20microscopy%20in%20human%20hair%20follicle%20sections%20revealed%20differential%20expression%20of%20ATP-binding%20cassette%20%28ABC%29%20transporters%20across%20the%20hair%20cycle.%20Cholesterol%20transporter%20expression%20%28ABCA1%2C%20ABCG1%2C%20ABCA5%20and%20SCARB1%29%20reduced%20as%20hair%20follicles%20transitioned%20from%20growth%20to%20regression.%20Staining%20for%20free%20cholesterol%20%28filipin%29%20revealed%20prominent%20cholesterol%20striations%20within%20the%20basement%20membrane%20of%20the%20hair%20bulb.%20Liver%20X%20receptor%20agonism%20demonstrated%20active%20regulation%20of%20ABCA1%20and%20ABCG1%2C%20but%20not%20ABCA5%20or%20SCARB1%20in%20human%20hair%20follicles%20and%20primary%20keratinocytes.%20These%20results%20demonstrate%20the%20capacity%20of%20human%20hair%20follicles%20for%20cholesterol%20transport%20and%20trafficking.%20Future%20studies%20examining%20the%20role%20of%20cholesterol%20transport%20across%20the%20hair%20cycle%20may%20shed%20light%20on%20the%20role%20of%20lipid%20homeostasis%20in%20human%20hair%20disorders.%22%2C%22date%22%3A%222021-01-06%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00418-020-01957-8%22%2C%22ISSN%22%3A%221432-119X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00418-020-01957-8%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-01-07T23%3A17%3A11Z%22%7D%7D%5D%7D
Palmer, M. A., Smart, E., & Haslam, I. S. (2021). Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle. Histochemistry and Cell Biology. https://doi.org/10.1007/s00418-020-01957-8 Cite
Full Article