Protective Role of ABCA1 in Ischemic Preconditioning Is Mediated by Downregulation of miR-33-5p and miR-135-5p

Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.
[Scientific Reports]
Sung, H. Y., Choi, E. N., Han, J., Chae, Y. J., Im, S.-W., Kim, H.-S., Park, E.-M., & Ahn, J.-H. (2021). Protective role of ABCA1 in ischemic preconditioning is mediated by downregulation of miR-33-5p and miR-135-5p. Scientific Reports, 11(1), 12511. https://doi.org/10.1038/s41598-021-91982-x Cite
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Human iPS Cells Engender Corneal Epithelial Stem Cells with Holoclone-Forming Capabilities

Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.
[iScience]
Watanabe, S., Hayashi, R., Sasamoto, Y., Tsujikawa, M., Ksander, B. R., Frank, M. H., Quantock, A. J., Frank, N. Y., & Nishida, K. (2021). Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102688 Cite
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The Inhibition of ABCB1/MDR1 or ABCG2/BCRP Enables Doxorubicin to Eliminate Liver Cancer Stem Cells

Scientists explored the role of inhibition of MDR1 or ABCG2 in sensitizing liver cancer stem cells to doxorubicin, the most frequently used chemotherapeutic agent in treating liver cancer.
[Scientific Reports]
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Mitochondrial ATP Fuels ABC Transporter-Mediated Drug Efflux in Cancer Chemoresistance

The authors investigated the energetic demands of ATP binding cassette (ABC) transporters in the context of the metabolic adaptations of chemoresistant cancer cells and developed methylation-controlled J protein mimetics that could attenuate mitochondrial respiration and safely overcome chemoresistance in vitro and in vivo.
[Nature Communications]
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white Regulates Proliferative Homeostasis of Intestinal Stem Cells during Aging in Drosophila

Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.
[Nature Metabolism]
Sasaki, A., Nishimura, T., Takano, T., Naito, S., & Yoo, S. K. (2021). white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila. Nature Metabolism, 1–12. https://doi.org/10.1038/s42255-021-00375-x Cite
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LAMC2 Promotes Cancer Progression and Gemcitabine Resistance through Modulation of EMT and ATP-Binding Cassette Transporters in Pancreatic Ductal Adenocarcinoma

Inhibition of Laminin γ2 (LAMC2) in pancreatic cancer (PC) cells enhanced the gemcitabine sensitivity and induction of apoptosis. It inhibited colony formation ability, migration, and invasion potential.
[Carcinogenesis]
Okada, Y., Takahashi, N., Takayama, T., & Goel, A. (2021). LAMC2 promotes cancer progression and gemcitabine resistance through modulation of EMT and ATP-binding cassette transporters in pancreatic ductal adenocarcinoma. Carcinogenesis, bgab011. https://doi.org/10.1093/carcin/bgab011 Cite
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Pentraxin 3 Acts as a Functional Effector of Akt/NF-κB Signaling to Modulate the Progression and Cisplatin-Resistance in Non-Small Cell Lung Cancer

The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.
[Archives of Biochemistry and Biophysics]
Li, Y., Song, X., Niu, J., Ren, M., Tang, G., Sun, Z., & Kong, F. (2021). Pentraxin 3 acts as a functional effector of Akt/NF-κB signaling to modulate the progression and cisplatin-resistance in non-small cell lung cancer. Archives of Biochemistry and Biophysics, 108818. https://doi.org/10.1016/j.abb.2021.108818 Cite
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ATP-Binding Cassette Transporters Restrict Drug Delivery and Efficacy against Brain Tumors Even when Blood-Brain Barrier Integrity Is Lost

A leaky vasculature resulted in higher docetaxel tumor levels compared to normal brain. Nevertheless, Abcb1 could reduce drug distribution and efficacy even in leaky models.
[Cell Reports Medicine]
Gooijer, M. C. de, Kemper, E. M., Buil, L. C. M., Çitirikkaya, C. H., Buckle, T., Beijnen, J. H., & Tellingen, O. van. (2021). ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost. Cell Reports Medicine, 2(1). https://doi.org/10.1016/j.xcrm.2020.100184 Cite
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Cholangiogenic Potential of Human Deciduous Pulp Stem Cell-Converted Hepatocyte-Like Cells

Stem cells from human exfoliated deciduous teeth-derived hepatocytes were intrasplenically transplanted into chronically CCl4-treated liver fibrosis model mice, followed by the analysis of donor integration and hepatobiliary metabolism in vivo.
[Current Stem Cell Research & Therapy]
Yuniartha, R., Yamaza, T., Sonoda, S., Yoshimaru, K., Matsuura, T., Yamaza, H., Oda, Y., Ohga, S., & Taguchi, T. (2021). Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells. Stem Cell Research & Therapy, 12(1), 57. https://doi.org/10.1186/s13287-020-02113-8 Cite
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Modulation of cAMP Metabolism for CFTR Potentiation in Human Airway Epithelial Cells

Human airway epithelial cells were used to test the efficacy of cyclic AMP modulation by ABCC4 and PDE-4 inhibition through a series of concentration–response studies.
[Scientific Reports]
Nguyen, J. P., Bianca, M., Huff, R. D., Tiessen, N., Inman, M. D., & Hirota, J. A. (2021). Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells. Scientific Reports, 11(1), 904. https://doi.org/10.1038/s41598-020-79555-w Cite
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CCAAT/Enhancer-Binding Protein Delta Mediates Glioma Stem-Like Cell Enrichment and ATP-Binding Cassette Transporter ABCA1 Activation for Temozolomide Resistance in Glioblastoma

Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery]
Wang, S.-M., Lin, W.-C., Lin, H.-Y., Chen, Y.-L., Ko, C.-Y., & Wang, J.-M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1–11. https://doi.org/10.1038/s41420-020-00399-4 Cite
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