Atypical Cyclin P Regulates Cancer Cell Stemness through Activation of the WNT Pathway

Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.
[Cellular Oncology]
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Polybrominated Diphenyl Ethers BDE-47 and BDE-99 Modulate Murine Melanoma Cell Phenotype In Vitro

Researchers investigated the effects of polybrominated diphenyl ethers used as flame retardants on phenotypic features of melanoma cells that are important for cancer.
[Environmental Science and Pollution Research]
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Identification of circ_0058357 as a Regulator in Non-small Cell Lung Cancer Cells Resistant to Cisplatin by miR-361-3p/ABCC1 Axis

Researchers identified the precise role of circular RNA circ_0058357 in the functional properties of DDP-resistant non-small cell lung cancer cells.
[Thoracic Cancer]
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Structures of ABCB4 Provide Insight into Phosphatidylcholine Translocation

Scientists presented cryogenic electron microscopy structures of human ABCB4 in three distinct functional conformations. They recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue.
[Proceedings of the National Academy of Sciences of the United States of America]
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Extracellular Matrix Protein-1 Secretory Isoform Promotes Ovarian Cancer through Increasing Alternative mRNA Splicing and Stemness

Investigators reported that the secretory extracellular matrix protein-1 isoform induced tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling.
[Nature Communications]
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Protective Role of ABCA1 in Ischemic Preconditioning Is Mediated by Downregulation of miR-33-5p and miR-135-5p

Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.
[Scientific Reports]
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Human iPS Cells Engender Corneal Epithelial Stem Cells with Holoclone-Forming Capabilities

Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.
[iScience]
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The Inhibition of ABCB1/MDR1 or ABCG2/BCRP Enables Doxorubicin to Eliminate Liver Cancer Stem Cells

Scientists explored the role of inhibition of MDR1 or ABCG2 in sensitizing liver cancer stem cells to doxorubicin, the most frequently used chemotherapeutic agent in treating liver cancer.
[Scientific Reports]
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Mitochondrial ATP Fuels ABC Transporter-Mediated Drug Efflux in Cancer Chemoresistance

The authors investigated the energetic demands of ATP binding cassette (ABC) transporters in the context of the metabolic adaptations of chemoresistant cancer cells and developed methylation-controlled J protein mimetics that could attenuate mitochondrial respiration and safely overcome chemoresistance in vitro and in vivo.
[Nature Communications]
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white Regulates Proliferative Homeostasis of Intestinal Stem Cells during Aging in Drosophila

Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.
[Nature Metabolism]
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LAMC2 Promotes Cancer Progression and Gemcitabine Resistance through Modulation of EMT and ATP-Binding Cassette Transporters in Pancreatic Ductal Adenocarcinoma

Inhibition of Laminin γ2 (LAMC2) in pancreatic cancer (PC) cells enhanced the gemcitabine sensitivity and induction of apoptosis. It inhibited colony formation ability, migration, and invasion potential.
[Carcinogenesis]
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