Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.
Inhibition of Laminin γ2 (LAMC2) in pancreatic cancer (PC) cells enhanced the gemcitabine sensitivity and induction of apoptosis. It inhibited colony formation ability, migration, and invasion potential.
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The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.
[Archives of Biochemistry and Biophysics]
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Li, Y., Song, X., Niu, J., Ren, M., Tang, G., Sun, Z., & Kong, F. (2021). Pentraxin 3 acts as a functional effector of Akt/NF-κB signaling to modulate the progression and cisplatin-resistance in non-small cell lung cancer. Archives of Biochemistry and Biophysics, 108818. https://doi.org/10.1016/j.abb.2021.108818 Cite
A leaky vasculature resulted in higher docetaxel tumor levels compared to normal brain. Nevertheless, Abcb1 could reduce drug distribution and efficacy even in leaky models.
[Cell Reports Medicine]
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Gooijer, M. C. de, Kemper, E. M., Buil, L. C. M., Çitirikkaya, C. H., Buckle, T., Beijnen, J. H., & Tellingen, O. van. (2021). ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost. Cell Reports Medicine, 2(1). https://doi.org/10.1016/j.xcrm.2020.100184 Cite
Stem cells from human exfoliated deciduous teeth-derived hepatocytes were intrasplenically transplanted into chronically CCl4-treated liver fibrosis model mice, followed by the analysis of donor integration and hepatobiliary metabolism in vivo.
[Current Stem Cell Research & Therapy]
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Yuniartha, R., Yamaza, T., Sonoda, S., Yoshimaru, K., Matsuura, T., Yamaza, H., Oda, Y., Ohga, S., & Taguchi, T. (2021). Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells. Stem Cell Research & Therapy, 12(1), 57. https://doi.org/10.1186/s13287-020-02113-8 Cite
Human airway epithelial cells were used to test the efficacy of cyclic AMP modulation by ABCC4 and PDE-4 inhibition through a series of concentration–response studies.
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Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery]
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Wang, S.-M., Lin, W.-C., Lin, H.-Y., Chen, Y.-L., Ko, C.-Y., & Wang, J.-M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1–11. https://doi.org/10.1038/s41420-020-00399-4 Cite
Researchers found that the expression of ABCA8, a member of ABCA subfamily transporters, was significantly increased in human pancreatic cancer (PC) cells after gemcitabine (GEM) treatment, as well as in established GEM-resistant PC cells.
[Cell Death Discovery]
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Yang, C., Yuan, H., Gu, J., Xu, D., Wang, M., Qiao, J., Yang, X., Zhang, J., Yao, M., Gu, J., Tu, H., & Gan, Y. (2021). ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-020-00390-z Cite
The authors demonstrated the capacity of human hair follicles for cholesterol transport and trafficking.
[Histochemistry and Cell Biology]
The transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-2B prostate cancer cells were compared for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation. Next-Gen sequencing detected 9409 and 7757 genes differentially expressed in LNCaP and C4-2B cells, compared to their parental counterparts.
Researchers established CPT11-resistant variants of three human colon cancer cell lines, and found that gain of the resistance elicited an up-regulation of aldo-keto reductase 1C3 in the cells.