Stem cells from human exfoliated deciduous teeth-derived hepatocytes were intrasplenically transplanted into chronically CCl4-treated liver fibrosis model mice, followed by the analysis of donor integration and hepatobiliary metabolism in vivo.
[Current Stem Cell Research & Therapy]
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Yuniartha, R., Yamaza, T., Sonoda, S., Yoshimaru, K., Matsuura, T., Yamaza, H., Oda, Y., Ohga, S., & Taguchi, T. (2021). Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells. Stem Cell Research & Therapy, 12(1), 57. https://doi.org/10.1186/s13287-020-02113-8 Cite
Human airway epithelial cells were used to test the efficacy of cyclic AMP modulation by ABCC4 and PDE-4 inhibition through a series of concentration–response studies.
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Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery]
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Wang, S.-M., Lin, W.-C., Lin, H.-Y., Chen, Y.-L., Ko, C.-Y., & Wang, J.-M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1–11. https://doi.org/10.1038/s41420-020-00399-4 Cite
Researchers found that the expression of ABCA8, a member of ABCA subfamily transporters, was significantly increased in human pancreatic cancer (PC) cells after gemcitabine (GEM) treatment, as well as in established GEM-resistant PC cells.
[Cell Death Discovery]
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Yang, C., Yuan, H., Gu, J., Xu, D., Wang, M., Qiao, J., Yang, X., Zhang, J., Yao, M., Gu, J., Tu, H., & Gan, Y. (2021). ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-020-00390-z Cite
The authors demonstrated the capacity of human hair follicles for cholesterol transport and trafficking.
[Histochemistry and Cell Biology]
The transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-2B prostate cancer cells were compared for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation. Next-Gen sequencing detected 9409 and 7757 genes differentially expressed in LNCaP and C4-2B cells, compared to their parental counterparts.
Researchers established CPT11-resistant variants of three human colon cancer cell lines, and found that gain of the resistance elicited an up-regulation of aldo-keto reductase 1C3 in the cells.
The authors concluded that MRP1 protected placental cells from methyl mercury-induced oxidative stress by exporting the toxic metal and by maintaining the placental cells’ glutathione status in equilibrium.
[Archives of Toxicology]
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Granitzer, S., Ellinger, I., Khan, R., Gelles, K., Widhalm, R., Hengstschläger, M., Zeisler, H., Desoye, G., Tupova, L., Ceckova, M., Salzer, H., & Gundacker, C. (2020). In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Archives of Toxicology. https://doi.org/10.1007/s00204-020-02900-5 Cite
Primary amniotic mesenchymal cells (AMCs), chorion cells and decidual cells were isolated from placental membranes of women with uncomplicated pregnancies at full-term using enzymatic digestion.
In isocitrate dehydrogenase 1-mutant glioma cells, the elevated 24(S)-hydroxycholesterol activated liver X receptors, which consequently accelerated the low-density lipoprotein receptor (LDLR) degradation by upregulating the inducible degrader of the LDLR.
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Yang, R., Zhao, Y., Gu, Y., Yang, Y., Gao, X., Yuan, Y., Xiao, L., Zhang, J., Sun, C., Yang, H., Qin, J., Li, J., Zhang, F., Zhang, L., & Ye, J. (2020). Isocitrate dehydrogenase 1 mutation enhances 24( S )-hydroxycholesterol production and alters cholesterol homeostasis in glioma. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01439-0 Cite
The authors identified potential GLI1 binding sites in the promoter region of six ABC transporters. Next, they investigated the binding of GLI1 using chromatin immunoprecipitation experiments and demonstrated that GLI1 transcriptionally regulated the identified ABC transporters. This research showed that chemoresistant cells express high levels of GLI1 and of the ABC transporters and that GLI1 inhibition disrupts the transporters up-regulation.
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Po, A., Citarella, A., Catanzaro, G., Besharat, Z. M., Trocchianesi, S., Gianno, F., Sabato, C., Moretti, M., De Smaele, E., Vacca, A., Fiori, M. E., & Ferretti, E. (2020). Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells. Scientific Reports, 10(1), 13988. https://doi.org/10.1038/s41598-020-70871-9 Cite