Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

Researchers investigated whether the blockade of ABCC1 affects prostate cancer cell proliferation using both in vitro and in vivo models.
[Cancers]
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Extracellular ATP Promotes Breast Cancer Invasion and Chemoresistance via SOX9 Signaling

Researchers showed that sex-determining region Y-box 9 (SOX9) was up-regulated after adenosine 5′-triphosphate treatment in breast cancer cells. In vitro invasion and migration assays demonstrated that knocking down SOX9 attenuated ATP-driven invasive capability.
[Oncogene]
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CircSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer by Targeting miR-520h/ABCG2 Pathway

The authors determined circSETD3 was significantly upregulated in gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines and the plasma of gefitinib-resistant NSCLC patients.
[Molecular Therapy-Nucleic Acids]
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SOX9 Enhances Sorafenib Resistance through Upregulating ABCG2 Expression in Hepatocellular Carcinoma

The authors found that sorafenib treatment increased the proportion of SOX9 positive cells in hepatocellular carcinoma (HCC) cell lines. Overexpression of exogenous SOX9 in HCC increased sorafenib resistance both in vitro and in vivo, whereas down-regulation led to inhibition of sorafenib resistance.
[Biomedicine & PharmacoTherapy]
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MicroRNA200a Enhances Antitumor Effects in Combination with Doxorubicin in Hepatocellular Carcinoma

Scientists investigated the effects of specific microRNA-200a (miR-200a) on hepatocellular carcinoma (HCC) tumor cell growth and effect of doxorubicin-mediated cytotoxicity. Their results showed miR-200a to be downregulated in human HCC and HCC tumor cell lines.
[Translational Oncology]
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