Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Researchers investigated the effects of polybrominated diphenyl ethers used as flame retardants on phenotypic features of melanoma cells that are important for cancer.
[Environmental Science and Pollution Research]
[zotpress userid=” items=’GETZ94V2′ style=’apa’ cite=’yes’]
Researchers identified the precise role of circular RNA circ_0058357 in the functional properties of DDP-resistant non-small cell lung cancer cells.
[zotpress userid=” items=’94JE87GF’ style=’apa’ cite=’yes’]
Scientists presented cryogenic electron microscopy structures of human ABCB4 in three distinct functional conformations. They recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=” items=’X5K64SXJ’ style=’apa’ cite=’yes’]
Investigators reported that the secretory extracellular matrix protein-1 isoform induced tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling.
[zotpress userid=” items=’SKS2G6DJ’ style=’apa’ cite=’yes’]
Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.
[zotpress userid=’7753456′ items=’JFX3IXKP’ style=’apa’ cite=’yes’]
Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.
[zotpress userid=” items=’NI32LKR7′ style=’apa’ cite=’yes’]
Scientists explored the role of inhibition of MDR1 or ABCG2 in sensitizing liver cancer stem cells to doxorubicin, the most frequently used chemotherapeutic agent in treating liver cancer.
[zotpress userid=” items=’CZTLUVH5′ style=’apa’ cite=’yes’]
The authors investigated the energetic demands of ATP binding cassette (ABC) transporters in the context of the metabolic adaptations of chemoresistant cancer cells and developed methylation-controlled J protein mimetics that could attenuate mitochondrial respiration and safely overcome chemoresistance in vitro and in vivo.
[zotpress userid=” items=’I2RZRKN8′ style=’apa’ cite=’yes’]
Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.
[zotpress userid=’6445212′ items=’B75YCBZW’ style=’apa’ cite=’yes’]
Inhibition of Laminin γ2 (LAMC2) in pancreatic cancer (PC) cells enhanced the gemcitabine sensitivity and induction of apoptosis. It inhibited colony formation ability, migration, and invasion potential.
[zotpress userid=’6606345′ items=’9ZASSL7V’ style=’apa’ cite=’yes’]