Significance of Aldo-Keto Reductase 1C3 and ATP-Binding Cassette Transporter B1 in Gain of Irinotecan Resistance in Colon Cancer Cells

Researchers established CPT11-resistant variants of three human colon cancer cell lines, and found that gain of the resistance elicited an up-regulation of aldo-keto reductase 1C3 in the cells.