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ATR

NBS1 Interacts With Notch Signaling in Neuronal Homeostasis

[Nucleic Acids Research] Nbs1 deletion was dispensable for postmitotic neurons, but compromised their arborization and migration due to dysregulated Notch signaling.

ATR Is Essential for Preservation of Cell Mechanics and Nuclear Integrity during Interstitial Migration

[Nature Communications] ATR-defective cells were defective in neuronal migration during development and in metastatic dissemination from circulating tumor cells.

PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

[Molecular Cell] Researchers report the histone acetyltransferase PCAF as a fork-associated protein that promotes fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replication forks, which recruits MRE11 and EXO1.

EB Virus-Induced ATR Activation Accelerates Nasopharyngeal Carcinoma Growth via M2-Type Macrophages Polarization

[Cell Death & Disease] Scientists showed that Epsteinā€“Barr virus could promote the expression of p-ATR and M2-type TAMs transformation in clinical nasopharyngeal carcinoma specimens.

Dynamic Remodelling of the Human Host Cell Proteome and Phosphoproteome upon Enterovirus Infection

[Nature Communications] The authors describe an unbiased, system-wide and time-resolved analysis of the proteome and phosphoproteome of human cells infected with coxsackievirus B3.

p53 Activation during Ribosome Biogenesis Regulates Normal Erythroid Differentiation

[Blood] A detailed characterization of ribosome biogenesis dynamics during human and murine erythropoiesis shows that ribosome biogenesis is abruptly interrupted by the drop of rDNA transcription and the collapse of ribosomal protein neo-synthesis.

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