Disturbance of Phylogenetic Layer-Specific Adaptation of Human Brain Gene Expression in Alzheimer’s Disease

Scientists identified Alzheimer’s disease (AD)-associated layer-specific differences involving protein-coding and non-coding sequences, most of those present in the subcortical white matter, thus indicating a critical role for long axons and oligodendrocytes in AD pathomechanism.
[Scientific Reports]
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Mesenchymal Stem Cells Act as Stimulators of Neurogenesis and Synaptic Function in a Rat Model of Alzheimer’s Disease

The possible roles of human umbilical mesenchymal stromal cord and adipose mesenchymal stem cells in neurogenesis and synaptic function were investigated using a β-amyloid 1-42-induced Alzheimer’s disease rat model.
[Heliyon]
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NAD+ Supplementation Reduces Neuroinflammation and Cell Senescence in a Transgenic Mouse Model of Alzheimer’s Disease via cGAS–STING

Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.
[Proceedings of the National Academy of Sciences of the United States of America]
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N-Acetylcysteine Prevents Amyloid-β Secretion in Neurons Derived from Human Pluripotent Stem Cells with Trisomy 21

Researchers established an in vitro cellular model using neurons differentiated from Down syndrome patient-derived induced pluripotent stem cells (iPSCs) and isogenic euploid iPSCs.
[Scientific Reports]
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N-Acetylcysteine Prevents Amyloid-β Secretion in Neurons Derived from Human Pluripotent Stem Cells with Trisomy 21

Investigators established an in vitro cellular model using neurons differentiated from Down syndrome (DS) patient-derived iPSCs and isogenic euploid iPSCs. Neurons differentiated from DS patient-derived iPSCs secreted more amyloid β compared to those differentiated from the euploid iPSCs.
[Scientific Reports]
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High-Content Image-Based Analysis and Proteomic Profiling Identifies Tau Phosphorylation Inhibitors in a Human iPSC-Derived Glutamatergic Neuronal Model of Tauopathy

Scientists used iPSCs from a patient carrying a p.A152T tau variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation.
[Scientific Reports]
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Modeling Sporadic Alzheimer’s Disease in Human Brain Organoids under Serum Exposure

Serum-exposed brain organoids are able to recapitulate Alzheimer’s disease-like pathologies, including increased amyloid beta aggregates and phosphorylated microtubule-associated tau protein level, synaptic loss, and impaired neural network.
[Advanced Science]
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A Novel Orally Active HDAC6 Inhibitor T-518 Shows a Therapeutic Potential for Alzheimer’s Disease and Tauopathy in Mice

Researchers characterized N-[(1R,2R)-2-{3-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl]-5-oxo-5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl}cyclohexyl]-2,2,3,3,3-pentafluoropropanamide (T-518), a novel, potent, highly selective histone deacetylase 6 inhibitor with clinically favorable pharmacodynamics.
[Scientific Reports]
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Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-kB-Mediated Production of CXCL1

Investigators reported that ApoE was elevated in peripheral blood monocytes in pancreatic ductal adenocarcinoma patients, and plasma ApoE protein levels stratified patient survival.
[Cancer Research]
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Overlapping Roles of JIP3 and JIP4 in Promoting Axonal Transport of Lysosomes in Human iPSC-Derived Neurons

Investigators established a hiPSC-derived neuron model for the investigation of axonal lysosome transport and maturation and showed that loss of JIP3 resulted in the accumulation of axonal lysosomes and the Alzheimer’s disease-related amyloid precursor protein-derived Aβ42 peptide.
[Molecular Biology of the Cell]
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Sex Differences in the Blood–Brain Barrier and Neurodegenerative Diseases

The authors describe sex-related differences in neurodegenerative diseases and the blood–brain barrier, whose dysfunction is linked to neurodegenerative disease development and progression.
[APL Bioengineering]
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