UCB Enters into Collaboration with Roche to Develop Antibody Treatment for People Living with Alzheimer’s Disease

UCB today announced an agreement to enter into a world-wide, exclusive license agreement with Roche and Genentech, a member of the Roche Group, for the global development and commercialization of UCB0107 in Alzheimer’s Disease.
[UCB]
Press Release

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AC Immune Advances phospho-Tau Alzheimer’s Vaccine in Phase Ib/IIa Study

AC Immune SA announced the initiation of the second highest dosing group in the company’s Phase Ib/IIa clinical trial evaluating ACI-35.030 for the treatment of Alzheimer’s disease.
[AC Immune]
Press Release

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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Investigators summarize and question what is known and remains to be discovered about the TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.
[Cell]
Full Article Continue reading “The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway”
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Reconstruction of the Human Blood-Brain Barrier In Vitro Reveals a Pathogenic Mechanism of APOE4 in Pericytes

Researchers revealed the role of pericytes in apolipoprotein (APOE4)-mediated cerebral amyloid angiopathy (CAA) and highlighted calcineurin-nuclear factor of activated T cells signaling as a therapeutic target in CAA and Alzheimer’s disease.
[Nature Medicine]
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Alzheimer’s-Associated PLCγ2 Is a Signaling Node Required for Both TREM2 Function and the Inflammatory Response in Human Microglia

The authors used genetically engineered human iPSC-derived microglia-like cells to show that triggering receptor expressed on myeloid cells 2 (TREM2) signaled through PLCγ2 to mediate cell survival, phagocytosis, processing of neuronal debris, and lipid metabolism.
[Nature Neuroscience]
Abstract

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Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

The authors validated defects in neuronal endosomal traffic by showing altered localization of amyloid precursor protein (APP) in early endosomes, a site of APP cleavage by the β-secretase.
[Cell Reports]
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30696-3 Cite
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Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

The authors validated defects in neuronal endosomal traffic by showing altered localization of amyloid precursor protein (APP) in early endosomes, a site of APP cleavage by the β-secretase.
[Cell Reports]
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30696-3 Cite
Full ArticleGraphical Abstract

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Common Germline Variants of the Human Apoe Gene Modulate Melanoma Progression and Survival

Scientists reported that, in a reversal of their effect on Alzheimer’s disease, the APOE4 and APOE2 variants conferred favorable and poor outcomes in melanoma, respectively.
[Nature Medicine]

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