ChK1 Activation Induces Reactive Astrogliosis through CIP2A/PP2A/STAT3 Pathway in Alzheimer’s Disease

Checkpoint kinase 1 (ChK1)-mediated Cancerous Inhibitor of PP2A (CIP2A) overexpression drove inhibition of PP2A and activated STAT3, then led to reactive astrogliosis and neurodegeneration in vitro.