Alzheimer's disease

[Molecular and Cellular Biochemistry] C57BL/6 mice were used to isolate and identify CD133+GFAP+CD117+Sca1+ cells in the hippocampal dentate gyrus region of the mouse brain as a novel neural stem cell population, in terms of cell phenotype, self-renewal capacity, and differentiation capability.

[Cell Reports] Scientists showed that the neuronal retromer could regulate Alzheimer's disease (AD)-associated pathologies in two of AD's principal cell types, which strengthened the link, and clarified the mechanism, between endosomal trafficking and late-onset sporadic AD.

[Aging Cell] Using 3xTg and APP/PS1 mouse models of Alzheimer's disease, and in vitro model of amyloid beta42 toxicity in primary neuronal cultures and SH-SY5Y neuroblastoma cells, scientists have uncovered a key role for cathepsin L in the induction of nuclear lamina damage.

[Current Opinion in Neurobiology] Scientists review the most recent advances in modeling Alzheimer's disease in organoids and other engineered 3D cell culture systems.

[Aging Cell] Scientists discuss how the risk factors for Alzheimer's disease (AD), particularly Apolipoprotein E, Aβ, α-secretase, β-secretase, γ-secretase, Tau, and neuroinflammation, modulate T-cell activation and the association between T cells and pathological AD hallmarks.

[Stem Cell Research & Therapy] Scientists review the studies on exosomes secreted by mesenchymal stem cells (MSC-EXOs) for drug delivery, summarize the characteristics of MSC-EXOs, and introduce the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.