Regulatory Role of Cathepsin L in Induction of Nuclear Laminopathy in Alzheimer’s Disease

Using 3xTg and APP/PS1 mouse models of Alzheimer’s disease, and in vitro model of amyloid beta42 toxicity in primary neuronal cultures and SH-SY5Y neuroblastoma cells, scientists have uncovered a key role for cathepsin L in the induction of nuclear lamina damage.