PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3

Researchers investigated mechanisms by which PAF1 maintains cancer stem cells and contributes to development of pancreatic tumors.
[Gastroenterology]
Karmakar, S., Rauth, S., Nallasamy, P., Perumal, N., Nimmakalaya, R. K., Leon, F., Gupta, R., Barkeer, S., Venkata, R. C., Raman, V., Rachagani, S., Ponnusamy, M. P., & Batra, S. K. (2020). PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.07.053 Cite
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Active Turnover of Genomic Methylcytosine in Pluripotent Cells

Scientists used metabolic labeling with stable isotopes and mass spectrometry to quantitatively address the global turnover of genomic 5-methyl-2′-deoxycytidine, 5-hydroxymethyl-2′-deoxycytidine and 5-formyl-2′-deoxycytidine across mouse pluripotent cell states.
[Nature Chemical Biology]
Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Arista, G., Kosmatchev, O., Korytiakova, E., Rahimoff, R., Ebert, C., & Carell, T. (2020). Active turnover of genomic methylcytosine in pluripotent cells. Nature Chemical Biology, 1–9. https://doi.org/10.1038/s41589-020-0621-y Cite
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The Proteomic Analysis of Breast Cell Line Exosomes Reveals Disease Patterns and Potential Biomarkers

Investigators tested three exosomes isolation methods and detergents for solubilization of exosomal proteins and enhanced detection by mass spectrometry.
[Scientific Reports]
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Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity

M1 and M2 macrophage viability and activation were mainly found to be unaffected by few‐layer graphene and MoS2 at doses up to 50 µg mL−1.
[Small]
Lin, H., Ji, D.-K., Lucherelli, M. A., Reina, G., Ippolito, S., Samorì, P., & Bianco, A. (n.d.). Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity. Small, n/a(n/a), 2002194. https://doi.org/10.1002/smll.202002194 Cite
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Extracellular ATP Promotes Breast Cancer Invasion and Chemoresistance via SOX9 Signaling

Researchers showed that sex-determining region Y-box 9 (SOX9) was up-regulated after adenosine 5′-triphosphate treatment in breast cancer cells. In vitro invasion and migration assays demonstrated that knocking down SOX9 attenuated ATP-driven invasive capability.
[Oncogene]
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Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

Scientists found that incorporation of the CD3ε cytoplasmic domain into a second-generation chimeric antigen receptor (CAR) improved antitumor activity of CAR-T cells.
[Cell]
Wu, W., Zhou, Q., Masubuchi, T., Shi, X., Li, H., Xu, X., Huang, M., Meng, L., He, X., Zhu, H., Gao, S., Zhang, N., Jing, R., Sun, J., Wang, H., Hui, E., Wong, C. C., & Xu, C. (2020). Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.07.018 Cite
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Proteomics Analysis of FUS Mutant Human Motoneurons Reveals Altered Regulation of Cytoskeleton and Other ALS-Linked Proteins via 3′UTR Binding

By taking advantage of a human induced pluripotent stem cell-based model, scientists aimed to gain insights on the impact of amyotrophic lateral sclerosis (ALS) mutant FUS on the motoneuron proteome.
[Scientific Reports]
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