mass spectrometry

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.

[Cell Death & Disease] Researchers reported on the novel mechanism whereby overexpressed class I histone deacetylases increase the resistance of glioblastoma cells to the SN1 methylating agent temozolomide.

[Molecular Cancer] The authors investigated the expression profile of circular RNAs in breast cancer MCF-7 cells under hypoxia and normoxia using microarray.

[Neuro-Oncology] The authors established the relevance of interclonal cross-talk between MYC-driven and non-MYC-driven medulloblastoma cells.

[Methods] Scientists designed a workflow to reproducibly extract proteins from brain organoids, measure global turnover using mass spectrometry, and statistically investigate turnover differences between genotypes.

[Cancer Research] The authors established cells with acquired resistance to the allosteric SHP2 inhibitor SHP099 from two FLT3-ITD-positive AML cell lines.