Alzheimer's disease

[Scientific Reports] Scientists used iPSCs from a patient carrying a p.A152T tau variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation.

[Advanced Science] Serum-exposed brain organoids are able to recapitulate Alzheimer's disease-like pathologies, including increased amyloid beta aggregates and phosphorylated microtubule-associated tau protein level, synaptic loss, and impaired neural network.

[Scientific Reports] Researchers characterized N-[(1R,2R)-2-{3-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl]-5-oxo-5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl}cyclohexyl]-2,2,3,3,3-pentafluoropropanamide (T-518), a novel, potent, highly selective histone deacetylase 6 inhibitor with clinically favorable pharmacodynamics.

[Cancer Research] Investigators reported that ApoE was elevated in peripheral blood monocytes in pancreatic ductal adenocarcinoma patients, and plasma ApoE protein levels stratified patient survival.

[Molecular Biology of the Cell] Investigators established a hiPSC-derived neuron model for the investigation of axonal lysosome transport and maturation and showed that loss of JIP3 resulted in the accumulation of axonal lysosomes and the Alzheimer's disease-related amyloid precursor protein-derived Aβ42 peptide.

[APL Bioengineering] The authors describe sex-related differences in neurodegenerative diseases and the blood–brain barrier, whose dysfunction is linked to neurodegenerative disease development and progression.