B cells

[iScience] Scientists performed phenotypic and functional characterization of peripheral blood immune cells from pediatric and adult-onset autoimmune thyroid disease (AITD) patients and age-matched controls using mass cytometry.

[Cell Reports] Scientists identified SARS-CoV-2 RNA-dependent RNA-polymerase as highly conserved likely due to its critical role in the virus life cycle.

[Cellular & Molecular Immunology] Researchers unveiled the guiding role of three essential factors, Lhx2, Hoxa9, and Runx1, the simultaneous expression of which preferentially drove B lineage fate commitment and in vivo B lymphopoiesis using PSCs as a cell source.

[Laboratory Investigation] Investigators provided evidence that elevated levels of human SMO showed a strong correlation with elevated levels of insulin-like growth factor 1 receptor and reduced survival in diffuse large B-cell lymphoma.

[Nature Medicine] Public transcriptomic datasets confirmed B cell maturation antigen (BCMA) RNA expression in the caudate of normal human brains, suggesting that this may be an on-target effect of anti-BCMA therapy.

[Nature Communications] The authors developed an anti-CD19 CAR comprised of the 4-1BB co-stimulatory and TNFRSF19 transmembrane domains, showing anti-tumor efficacy in an in vivo xenograft lymphoma model.