B cells

[Nature Reviews Clinical Oncology] Scientists provide an overview of T cell costimulation by CD28 and 4-1BB and, using the available preclinical and clinical data, compare the efficacy and toxicity profiles associated with CARs containing either costimulatory domain.

[Clinical Cancer Research] The authors review the known functions of B-cells in the tumor microenvironment, the contribution of B-cells to the anti-tumor activity of immunotherapies, and the role of B-cells in the overall survival of cancer patients.

[Leukemia] Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the angioimmunoblastic T-cell lymphoma tumor microenvironment.

[Laboratory Investigation] The authors investigated the role of hypoxia/serum deprivation-induced M1-type macrophage-derived exosomes on bone marrow MSC viability, migration, and apoptosis.

[Leukemia] The authors built mouse models expressing activated Il7r (aIL7R). B-cell intrinsic aIL7R mice developed spontaneous B-cell acute lymphoblastic leukemia, demonstrating sufficiency of Il7r activating mutations in leukemogenesis.

[Haematologica] Tafasitamab combined with the immunomodulatory drug lenalidomide was clinically active with a good tolerability profile in the open-label, single-arm, phase II L-MIND study of autologous stem-cell transplant-ineligible patients with relapsed/refractory diffuse large B-cell lymphoma.