B cells

[Journal of Photochemistry and Photobiology B-Biology] Researchers found that blue light-induced oxidative stress triggered the endoplasmic reticulum stress-C/EBP homologous protein signal and affected the protein levels of B-cell lymphoma-2 (Bcl-2) and Bcl2-associated X, thereby promoting apoptosis.

[Nature Medicine] Researchers investigated the role of the intestinal microbiome onvarious outcomes in a multicenter study of patients with B cell lymphoma and leukemia.

[iScience] Researchers designed a lipid nanoparticle-encapsulated, nucleoside-unmodified mRNA vaccine encoding the trimerized receptor binding domain and showed its robust capability in inducing broad and protective immune responses against wildtype and major variants of concern in the mouse model of SARS-CoV-2 infection.

[Cell Reports] Scientists showed that B cell responses remained T cell dependent in constitutive Wiskott-Aldrich syndrome protein (WASp)-deficient mice, whereas selective WASp deletion in germinal center B cells was sufficient to induce broad development of self-reactive antibodies and kidney pathology.

[NPJ Genomic Medicine] Investigators identified a recurrent mutation at position c.28 in the gene encoding the snRNA U2. This mutation was present in B cell derived tumors, as well as in prostate and pancreatic cancer, suggesting U2 c.28 constitutes a driver candidate associated with worse prognosis.

[Nature Reviews Immunology] The author discuss the increase in circulating Follicular helper T cells seen in autoimmune settings and explore potential explanations for this phenomenon.