BDNF

[BMC Neuroscience] The inner surface of electrospun poly nanofibrous conduit was biofunctionalized with laminin containing brain derived neurotrophic factor (BDNF) and gold nanoparticles in chitosan nanoparticle.

[Journal of Molecular Neuroscience] After stimulation with Zeb2/Axin2-enriched BMSC exosomes, the spatial memory and nerve function of MCAO rats showed marked recovery. The number of neurons was increased in the subventricular zone, hippocampus, and cortex area, while the expression of nerve growth factors was upregulated.

[nan] Scientists identified a microRNA that altered related components of the transport machinery to affect brain-derived neurotrophic factor retrograde signaling deficits in Alzheimer’s disease.

[Cell Reports] Researchers studied the effects of the balance between inhibitory and excitatory spontaneous neurotransmission on brain-derived neurotrophic factor (BDNF) regulation and synaptic plasticity.

[Neuropsychopharmacology] Researchers show that reduced BDNF and GABA also co-occur with attenuated autophagy in human depression.

[Nature Communications] Brain-derived neurotrophic factor (BDNF) is essential for adult synaptic plasticity and its pathway is associated with major depression and posttraumatic stress disorder. Researchers found that stress-enhanced matrix metalloproteinase 9 (MMP9) secretion increased the cleavage of proBDNF to its mature form mBDNF.