Tag results:
CD8
Human Immunology News
Heritable Changes in Division Speed Accompany the Diversification of Single T Cell Fate
[Proceedings of the National Academy of Sciences of the United States of America] Scientists utilized continuous live-cell imaging in vitro to track the division speed and genealogical connections of all descendants derived from a single naive CD8+ T cell throughout up to ten divisions of activation-induced proliferation.
Immunology of Infectious Disease News
Group 1 ILCs Regulate T Cell–Mediated Liver Immunopathology by Controlling Local IL-2 Availability
[Science Immunology] Scientists used multiphoton intravital microscopy in mouse models of hepatitis B to study the intrahepatic behavior of group 1 innate lymphoid cells (ILCs) and their cross-talk with hepatitis B virus–specific CD8+ T cells.
Immune Regulation News
In Vitro and In Vivo Functions of T Cells Produced in Complemented Thymi of Chimeric Mice Generated by Blastocyst Complementation
[Scientific Reports] Researchers generated thymus-complemented chimeric mice, assessed the efficacy of anti-PD-L1 antibody in tumor-bearing chimeric mice, and then investigated T cell function.
Human Immunology News
Increased Cytotoxic T Cells in the Airways of Adults with Former Bronchopulmonary Dysplasia
[European Respiratory Journal] The total number of cells and the differential cell counts in bronchoalveolar lavage were similar among the study groups.
Human Immunology News
Revealing the Transcriptional Heterogeneity of Organ-Specific Metastasis in Human Gastric Cancer Using Single-Cell RNA Sequencing
[Clinical and Translational Medicine] Ten fresh human tissue samples from six patients, including primary tumor and adjacent non-tumoral samples and six metastases from different organs or tissues were evaluated using single-cell RNA sequencing.
Human Immunology News
Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression
[Molecular & Cellular Proteomics] Co-culturing primary CD8+ T cells with Tregs only modestly affected the CD8+ surfaceome but did partially reverse activation-induced surfaceomic changes.