CD8

[eLife] Scientists identified Zfp335 transcription factor as a new player in the regulatory network controlling thymocyte development in mice.

[Journal of Experimental Medicine] The authors investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer.

[Journal of Clinical Investigation] Investigators observed that anti–PD-1 therapy depends on IL-2 signaling, which raised the possibility that a lack of IL-2 limited anti–PD-1–induced effector T cell expansion.

[Science Advances] eEF-2K KO CD8+ T cells were more metabolically active and showed hyperactivation of the Akt-mTOR-S6K pathway.

[Science Advances] The authors demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer.

[Nature] CAR T cells remained detectable more than ten years after infusion, with sustained remission in both patients.