CD8

[Journal of Experimental Medicine] Scientists used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells, which associated with prolonged allograft survival.

[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.

[Immunological Reviews] The authors detail the inflammatory and chemokine regulators of spatially restricted T cell differentiation, with a focus on how to promote stem-like memory cell.

[Immunity] Inhibition of IL-10R signaling altered chromatin accessibility and disrupted cooperativity between the transcription factors NFAT and AP-1, promoting a distinct NFAT-associated program.

[Biomedicine & Pharmacotherapy] Scientists investigated whether Abn-CBD can modulate the inflammatory response during type 1 diabetes (T1D) onset using a mouse model of T1D and of beta cell damage.

[Neurology-Neuroimmunology & Neuroinflammation] Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4.