CD8

[Cell Reports] In three murine models, CD8+ cells bearing resident memory T cells markers remained in previously inflamed joints during remission.

[Science Immunology] Researchers used an orthotopic non–small cell lung cancer mouse model to study immune checkpoint blockade-refractory CD8+ T cell responses.

[Cell Death & Disease] The authors found that apoptosis-associated epitopes-specific CD8+ T cells were present in the lymphoid organs of unprimed mice, proliferated under peptide stimulation in vitro, but failed to respond to peptide immunization in vivo, suggesting a physiological control of this response.

[Scientific Reports] To study Hsp70 forms released from cells scientists employed the assay consisting of two affinity chromatography methods. Hsp70 content in culture medium and extracellular vesicles was measured with the aid of ELISA.

[Nature Communications] Scientists showed that chemotherapy-induced anti-cancer immunity was suppressed by the tumor microenvironment through production of the cytokine IL-6.

[Gut] FVB/NJ mice were hydrodynamically injected with AKT/Ras and Sleeping Beauty transposon to induce hepatocellular carcinoma. Mini-circle and Sleeping Beauty were used to overexpress microRNA-206 in Kupffer cells of mice.