CD8

[Science Translational Medicine] Ex vivo treatment of mouse and human dendritic cells promoted their IFN1-dependent activation, and vaccination studies in mice demonstrated stimulation of antigen cross-presentation and T cell priming in vivo.

[Science Translational Medicine] Serotonin enhanced expression of PD-L1 on mouse and human cancer cells in vitro via serotonylation, which is the formation of covalent bonds between glutamine residues and serotonin, resulting in activation of small G proteins.

[Food & Function] The effects and pharmacological mechanisms of BRPS on the treatment of lung cancer were investigated both in vitro and in vivo.

[Scientific Reports] Scientists developed a system in which cytokine may be administered intravenously without toxic side effects. MSC were used as carriers of the IL-12.

[Science] Vaccine-specific CD4+ T cell, CD8+ T cell, binding antibody, and neutralizing antibody responses to the 25-μg Moderna mRNA-1273 vaccine were examined over seven months post-immunization.

[Frontiers in Immunology] Investigators enriched ubiquitinated proteins (UPs) from epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cancer cell line and tested the efficacy of α-Al2O3-UPs-4T1/EPB as therapeutic vaccine alone and in combination with the stimulator of interferon genes (STING) agonist in mice with drug-resistant and metastatic breast cancer.