CD8

[Cellular & Molecular Immunology] Researchers reported that serine/arginine splicing factor 1 (SRSF1) intrinsically regulated invariant natural killer T cell development by directly targeting Myb and balancing the abundance of short and long isoforms.

[Immunity] Expanded resident memory populations were present in melanoma-involved lymph nodes from patients, and their transcriptional signature predicted better survival.

[Cell Reports] Using two independent models, scientists showed that CD4 T cell help enhanced CD8 effector functions and prevented CD8 T cell exhaustion.

[Advanced Materials] High-pressure homogenization is utilized to drive immunomodulator IL10-modified bacteria to extrude through the gap and self-assembled into bacterial biomimetic vesicles exposing IL10 on the surface with high efficiency.

[Cancer Cell] Investigators reported that a bifunctional fusion protein that simultaneously inhibited TGF-β and PD-L1, bintrafusp alfa, effectively synergized with radiotherapy, leading to superior survival in multiple therapy-resistant murine tumor models with poor immune infiltration.

[npj Vaccines] Scientists described the adjuvant properties of a small molecule activator of the integrins αLβ2 and α4β1, named 7HP349, which could be safely delivered systemically independent of antigen.