CD8

[Science Translational Medicine] Scientists performed single-cell RNA sequencing on affected and unaffected skin from patients with vitiligo, as well as healthy controls, to define the role of each cell type in coordinating autoimmunity during disease progression.

[Modern Pathology] Researchers investigated VISTA expression and determine its associations with clinicopathological features, molecular subtypes, programmed cell death-ligand 1 expression, CD8+ T-cell count, and survival in a cohort of 839 patients with endometrial cancer.

[Stem Cell Research & Therapy] Modified mixed leukocyte reaction was performed between feline adipose-derived MSCs and PBMCs. Changes of cell cycle stages, phenotype and cellular senescence were determined through flow cytometry and gene expression analysis.

[Nature Communications] Using murine melanoma, the combined effect of cyclophosphamide preconditioning, CD4post, and ex vivo primed tumor-reactive CD8+ T cell infusion is presented.

[Science Immunology] The authors found that a small number of TCF1+ tumor-specific CD8+ T cells were present in lung tumors throughout their development.

[eLife] To gain functional insights into these tissue-resident intestinal intraepithelial T lymphocytes, the authors used high-resolution, quantitative mass spectrometry to compare the proteomes of induced tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) and natural T-IEL subsets, with naive CD8+ T cells from lymph nodes.