CD8

[Biochemical Society Transactions] Investigators provide a comprehensive overview of physiologically conserved or novel mechanisms utilized by tumor cells to reduce MHC-I or MHC-II expression.

[Cell Death & Disease] The authors observed that the protection against IAV after active vaccination with matrix protein 2 ectodomain viral antigen was lost was Ripk3−/− mice.

[American Journal of Respiratory and Critical Care Medicine] Researchers characterized the functional SARS-CoV-2 T cell responses in severe versus recovered, mild COVID-19 patients to determine whether differences were detectable.

[Cell] The authors identified a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors.

[Molecular Therapy-Methods & Clinical Development] Investigators showed that these self-amplifying mRNA SARS-CoV-2 vaccines raised potent neutralizing antibody responses in mice against not only the original virus but also the alpha, beta, gamma, and delta variants.

[Molecular Carcinogenesis] Scientists hypothesized that TGF-β receptor inhibition may alter Pancreatic ductal adenocarcinoma progression and antitumor immunity in the tumor microenvironment.