COPD

[Cell Biochemistry and Biophysics] Researchers investigated the role of lysocardiolipin acyltransferase expression and activity in mitochondrial oxidative stress, mitochondrial dynamics, and lung epithelial cell apoptosis.

[Cell Death & Disease] Scientists provide evidence for PRMT7’s function in regulating alveolar myofibroblasts proliferation and differentiation during lung alveologenesis.

[Hypertension] Scientists confirmed that EPAS1-specific inhibitor PT2385 ameliorated HPH features, as demonstrated by right ventricle hypertrophy, right ventricular systolic pressure, and pulmonary vascular remodeling.

[Mediators of Inflammation] Peripheral blood endothelial progenitor cells were isolated from nonsmoking non-chronic obstructive pulmonary disease (COPD), smoking non-COPD, and smoking COPD patients. The expressions of p16, p300, and senescence-related genes were detected by RT-PCR and Western Blot.

[Stem Cells Translational Medicine] Allogeneic, bone marrow-derived MSCs were systemically administered into patients with stable chronic obstructive pulmonary disease. Gene expression profiles from peripheral blood mononuclear cells were analyzed across the first week after infusion.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.