COPD

[Scientific Reports] Scientists characterized the immune processes induced by the epithelium after urban particulate matter exposure in special regard to interactions with monocyte-derived dendritic cells and monocyte-derived macrophages in obstructive lung diseases.

[Teva Pharmaceuticals, Ltd.] Teva Pharmaceuticals, Ltd. announced its US launch of the first generic version of twice daily PERFOROMIST®,formoterol fumarate inhalation solution, 20 mcg/2 ML, indicated to treat bronchoconstriction in patients with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.

[Ebiomedicine] Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.

[Molecular Medicine] Lung function and inflammatory cell infiltration were determined and the production of Muc5AC, TNF-α, IL-6, IL-8 in the bronchoalveolar lavage fluid (BALF) was assayed by ELISA. The effect of HSP72 and JNK on chronic obstructive pulmonary disease following treatment with baicalin was assessed both in vivo and in vitro by conducting loss- and gain- function experiments.

[Experimental & Molecular Medicine] Researchers evaluated the effect of Slit2 on the proliferation and migration of mouse lung epithelial cells and its role in regeneration in an emphysema lung mouse model.

[Experimental and Molecular Medicine] Scientists evaluated the effect of neutrophil elastase on lipopolysaccharide - induced interleukin 8 production and determined the molecular mechanism in human bronchial epithelial cells.