CXCL10

[Cell Death & Disease] Researchers focus on toll-like receptor-3 (TLR3) that was activated by double-strand RNA and promoted neuroinflammation.

[Cancer Immunology Immunotherapy] Researchers investigated whether and how N-803 improves hematopoietic progenitor cell-natural killer cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice.

[Cell] Applying multimodal single-cell analyses, investigators elucidated a heterogeneous but spatially defined central nervous system (CNS)-myeloid response during brain metastasis (br-met) outgrowth. We found Ccr2+ bone-marrow-derived myeloid cells minimally influenced br-met while CNS-myeloid promoted br-met outgrowth.

[EMBO Journal] Researchers showed that inhibition of N6‐methyladenosine mRNA modification by depletion of methyltransferases enhanced response to anti‐PD‐1 treatment in pMMR‐MSI‐L colorectal cancer and melanoma.

[Cancers] Researchers investigated whether the down-regulation of Scm-like with four mbt domains 2 (SFMBT2) regulated the infiltration of preadipocytes and tumor-associated macrophages in prostate cancer.

[Epigenetics] Investigators performed methylation loci fine-mapping to search the top signals in the entire CYP2S1 gene region, and further carried out gene expression assay, cell proliferation, apoptosis, differentiation and migration in CYP2S1 overexpressed (CYP2S1over) and silenced human keratinocytes.