EGFR

[Oncogene] Scientists showed that dopamine and cyclic AMP-regulated phosphoprotein, Mr 32000 physically recruited ERBB3 to epidermal growth factor receptor (EGFR) to mediate switching from EGFR homodimers to EGFR:ERBB3 heterodimers to bypass EGFR tyrosine kinase inhibitor -mediated inhibition by potentiating ERBB3-dependent activation of oncogenic signaling.

[FEBS Journal] Scientists reported on the epidermal growth factor receptor (EGFR)-estrogen receptor beta (ERβ) functional relationship in connection to the aggressiveness and cancer stem cell-like characteristics of triple-negative breast cancer cells.

[Biomedicine & Pharmacotherapy] Researchers characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro.

[Nature Communications] Hypothesizing that EGFR mutations alter tumor-immune interactions, scientists compared tumor-infiltrating lymphocytes between EGFR mutant and wild type tumors through single-cell transcriptomic analysis.

[iScience] Scientists reported that neutrophil elastase triggered dose-dependent ERK signaling and cell migration in a panel of prostate cell lines representing the spectrum of prostate cell malignancy.

[ESMO Open] In this review, the post-osimertinib treatment options for EGFR-mutated non-small-cell lung cancer are analyzed, with an outlook to ongoing clinical trials.