EGFR

[npj Precision Oncology] A patient-derived cell line obtained at the time of disease progression was used to identify NRAS gene amplification as an additional driver of drug resistance to combination EGFR/MET therapies.

[Cell Reports] Researchers used surface markers of resistant basal cell carcinomas and patient single-cell and bulk transcriptomic data, and uncovered the dynamic roadmap of basal to squamous cell carcinoma transition.

[Modern Pathology] In this review, scientists address the state of PD-L1 testing in lung cancer, the role for tumor mutation burden as a predictive biomarker

[Scientific Reports] Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.

[Journal of Cell Biology] Researchers conducted culture experiments that proved epidermal growth factor receptor (EGFR) activation drove human keratinocyte stem cell motility.

[Acta Pharmacologica Sinica] Researchers examined the ability of three different G-protein-coupled receptor (GPCR) agonists to reverse signaling inhibition and ameliorate rash induced by epidermal growth factor receptor inhibitors (EGFRi).