EGFR

[Molecular Biology Reports] The authors provide a summary of current findings on non-coding RNAs (ncRNAs) dysregulation after irradiation and present the function and mechanism of ncRNAs in modulating radiosensitivity or radioresistance of breast cancer cells.

[Proceedings of the National Academy of Sciences of the United States of America] The authors developed a platform integrated with a newly curated tumor surfaceome classifier that allowed profiling of primary 3D cultures and intact patient glioma tumors with preserved tissue architecture.

[Oncogene] Epidermal growth factor (EGF)/EGF receptor (EGFR) signaling upregulated T-box 19 (TBX19) expression via ERK/NF-kB pathway and TBX19 fostered HCC metastasis by enhancing EGFR and Rac family small GTPase 1 (RAC1) expression, which formed an EGF-TBX19-EGFR positive feedback loop.

[Journal of Liposome Research] Investigators developed the liposomal formulation, by ether injection method, comprising erlotinib, a tyrosine kinase EGFR inhibitor, proposed to be targeted through enhanced permeability and retention effect effect against pancreatic cancer.

[Cell Death & Disease] The authors studied the specific function of Numb-PRRL isoform in activated EMT of pancreatic ductal adenocarcinoma, which was distinguished from our previous studies that only focused on the total Numb protein.

[Communications Biology] The authors showed that clinically, plasma interleukin-6 (IL-6) level predicted osimertinib efficacy in epidermal growth factor receptor mutant NSCLC patients.