T-Box Transcription Factor 19 Promotes Hepatocellular Carcinoma Metastasis through Upregulating EGFR and RAC1

Epidermal growth factor (EGF)/EGF receptor (EGFR) signaling upregulated T-box 19 (TBX19) expression via ERK/NF-kB pathway and TBX19 fostered HCC metastasis by enhancing EGFR and Rac family small GTPase 1 (RAC1) expression, which formed an EGF-TBX19-EGFR positive feedback loop.