Daiichi Sankyo Announces Clinical Trial Collaboration with AstraZeneca to Evaluate Patritumab Deruxtecan (U3-1402) in Combination with TAGRISSO in EGFR-Mutated Non-Small Cell Lung Cancer

Daiichi Sankyo Company, Limited announced that it has entered into a clinical trial collaboration with AstraZeneca to evaluate the combination of patritumab deruxtecan, a HER3 directed DXd antibody drug conjugate, and TAGRISSO, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with EGFR-mutated advanced or metastatic non-small cell lung cancer.
[Daiichi Sankyo Company, Limited]
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Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
[Cancers]
Singh, C. K., Chhabra, G., Ndiaye, M. A., Siddiqui, I. A., Panackal, J. E., Mintie, C. A., & Ahmad, N. (2020). Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers, 12(8), 2141. https://doi.org/10.3390/cancers12082141 Cite
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Polydatin Executes Anticancer Effects against Glioblastoma Multiforme by Inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail Signaling Pathway

The authors demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
[Life Sciences]
Chen, Y., Niu, J., Li, L., Li, Z., Jiang, J., Zhu, M., Dong, T., Zhang, J., Shi, C., Xu, P., Lu, Y., Jiang, Y., Liu, P., & Chen, W. (2020). Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway. Life Sciences, 118158. https://doi.org/10.1016/j.lfs.2020.118158 Cite
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Cytovia Therapeutics Acquires Worldwide Rights to CytoImmune Therapeutics’ First-In-Class EGFR Dual-Targeting CAR for NK Cell Treatment of Glioblastoma & Other Solid Tumors

Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
Press Release

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Small Cell Transformation of ROS1 Fusion-Positive Lung Cancer Resistant to ROS1 Inhibition

Evidence of small cell transformation was observed in all metastatic sites at autopsy, with inactivation of RB1 and TP53, and loss of ROS1 fusion expression.
[npj Precision Oncology]
Lin, J. J., Langenbucher, A., Gupta, P., Yoda, S., Fetter, I. J., Rooney, M., Do, A., Kem, M., Chang, K. P., Oh, A. Y., Chin, E., Juric, D., Corcoran, R. B., Dagogo-Jack, I., Gainor, J. F., Stone, J. R., Lennerz, J. K., Lawrence, M. S., Hata, A. N., … Shaw, A. T. (2020). Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition. Npj Precision Oncology, 4(1), 1–8. https://doi.org/10.1038/s41698-020-0127-9 Cite
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Hotspot Mutant p53-R273H Inhibits KLF6 Expression to Promote Cell Migration and Tumor Metastasis

Scientists revealed an important role for EGFR–AKT–FOXO1–KLF6–E-cadherin axis in mutant p53-induced cell migration and tumor metastasis.
[Cell Death & Disease]
Sun, S., Chen, H., Sun, L., Wang, M., Wu, X., & Xiao, Z.-X. J. (2020). Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis. Cell Death & Disease, 11(7), 1–9. https://doi.org/10.1038/s41419-020-02814-1 Cite
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Unique Targeting of Androgen‐Dependent and ‐Independent AR Signaling in Prostate Cancer to Overcome Androgen Resistance

The authors investigated the ability of novel anti‐cancer agents, Dp44mT and DpC, to overcome androgen resistance. The effect of Dp44mT and DpC on androgen‐dependent and independent androgen receptor signaling was assessed in androgen‐dependent and ‐independent prostate cancer cells using 2D‐ and 3D‐tissue culture.
[FASEB Journal]
Lim, S. C., Jansson, P. J., Assinder, S. J., Maleki, S., Richardson, D. R., & Kovacevic, Z. (n.d.). Unique targeting of androgen-dependent and -independent AR signaling in prostate cancer to overcome androgen resistance. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.201903167R Cite
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Progesterone Receptor Membrane Component 1 Promotes the Growth of Breast Cancers by Altering the Phosphoproteome and Augmenting EGFR/PI3K/AKT Signalling

Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
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Hotspot Mutant p53-R273H Inhibits KLF6 Expression to Promote Cell Migration and Tumor Metastasis

Researchers demonstrated that hotspot mutant p53, p53-R273H, promoted cell scattering growth and migration via inhibiting the expression of Krupple-like factor 6 (KLF6), a Zinc finger transcription factor and a documented tumor suppressor.
[Cell Death & Disease]
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Ubiquilin Proteins Regulate EGFR Levels and Activity in Lung Adenocarcinoma Cells

The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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Expression of UDP Glucuronosyltransferases 2B15 and 2B17 Is Associated with Methylation Status in Prostate Cancer Cells

The expression of UGT2B15, UGT2B17, de novo methyltransferases, DNMT3A and DNMT3B was assessed in prostate cancer cells treated with EGF, an EGFR inhibitor PD16893, and the methyltransferase inhibitor, 5-azacytidine, respectively.
[Epigenetics]
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HCMV-Induced Signaling through GB–EGFR Engagement Is Required for Viral Trafficking and Nuclear Translocation in Primary Human Monocytes

Researchers showed that human cytomegalovirus induced chronic and functional EGFR signaling that was distinct to the virus as compared to the natural EGFR ligand: EGF.
[Proceedings of the National Academy of Sciences of the United States of America]
Fulkerson, H. L., Chesnokova, L. S., Kim, J. H., Mahmud, J., Frazier, L. E., Chan, G. C., & Yurochko, A. D. (2020). HCMV-induced signaling through gB–EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2003549117 Cite
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