Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-small Cell Lung Cancer: A Review

The authors critically analyse the mechanisms of epidermal growth factor receptor expression in non-small cell lung cancer (NSCLC), its relevance to currently approved targeted treatment options, and the complex nature of secondary mutations and intrinsic and acquired resistance patterns in NSCLC.
[Cells]
Karlsen, E.-A., Kahler, S., Tefay, J., Joseph, S. R., & Simpson, F. (2021). Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-Small Cell Lung Cancer: A Review. Cells, 10(5), 1206. https://doi.org/10.3390/cells10051206 Cite
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MCM8 Is Regulated by EGFR Signaling and Promotes the Growth of Glioma Stem Cells through Its Interaction with DNA-Replication-Initiating Factors

The role of mini-chromosome maintenance 8 (MCM8) in glioblastomas has remained unclear. Scientists investigated the biological functions and mechanisms of MCM8 in glioma stem cells.
[Oncogene]
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Assessment of Copy Number in Protooncogenes Are Predictive of Poor Survival in Advanced Gastric Cancer

Researchers characterized the clinicopathological features, including prognosis, of gastric carcinomas with copy number gains in multiple protooncogenes.
[Scientific Reports]
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Extensive Remodeling of the Extracellular Matrix during Aging Contributes to Age-Dependent Impairments of Muscle Stem Cell Functionality

Scientists used quantitative mass spectrometry to characterize intrinsic changes in the muscle stem cell (MuSC) proteome and remodeling of the MuSC niche during aging.
[Cell Reports]
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RAL GTPases Mediate EGFR-Driven Intestinal Stem Cell Proliferation and Tumorigenesis

In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.
[eLife]
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Collective ERK/Akt Activity Waves Orchestrate Epithelial Homeostasis by Driving Apoptosis-Induced Survival

The authors observed waves of extracellular-signal-regulated kinase (ERK) and AKT serine/threonine kinase (Akt) activity pulses that originate from apoptotic cells and propagate radially to healthy surrounding cells. This requires epidermal growth factor receptor (EGFR) and matrix metalloproteinase signaling.
[Developmental Cell]
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ADAM10 and ADAM17 Regulate EGFR, C-Met and TNF RI Signalling in Liver Regeneration and Fibrosis

Investigators showed that while ablation of ADAM17 resulted in decreased shedding of TNF RI, ADAM10 deficiency led to increased levels of soluble TNF RI in serum.
[Scientific Reports]
Zbodakova, O., Chalupsky, K., Sarnova, L., Kasparek, P., Jirouskova, M., Gregor, M., & Sedlacek, R. (2021). ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis. Scientific Reports, 11(1), 11414. https://doi.org/10.1038/s41598-021-90716-3 Cite
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Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma

Researchers examined the ability of patient-derived organoids to predict clinical responses to targeted therapies in individual patients and to identify effective anti-cancer therapies for novel molecular targets.
[Clinical Cancer Research]
Modeling clinical responses to targeted therapies by patient-derived organoids of advanced lung adenocarcinoma | Clinical Cancer Research. (n.d.). Retrieved June 4, 2021, from https://clincancerres.aacrjournals.org/content/early/2021/06/03/1078-0432.CCR-20-5026 Cite
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Tumor Suppressive Role of miR-342-5p in Human Chondrosarcoma Cells and 3D Organoids

The authors carried out high-throughput functional screening using impedancemetry, and identified five miRNAs with potential antiproliferative or chemosensitive effects on SW1353 chondrosarcoma cells.
[International Journal of Molecular Sciences]
Veys, C., Benmoussa, A., Contentin, R., Duchemin, A., Brotin, E., Lafont, J. E., Saintigny, Y., Poulain, L., Denoyelle, C., Demoor, M., Legendre, F., & Galéra, P. (2021). Tumor Suppressive Role of miR-342-5p in Human Chondrosarcoma Cells and 3D Organoids. International Journal of Molecular Sciences, 22(11), 5590. https://doi.org/10.3390/ijms22115590 Cite
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Peptide-Tiling Screens of Cancer Drivers Reveal Oncogenic Protein Domains and Associated Peptide Inhibitors

Pooled fitness screens in two breast cancer cell lines revealed peptides, which selectively reduced cellular proliferation, implicating oncogenic protein domains important for cell fitness.
[Cell Systems]
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Cell Surface Integrin α5ß1 Clustering Negatively Regulates Receptor Tyrosine Kinase Signaling in Colorectal Cancer Cells via Glycogen Synthase Kinase 3

The clustering of integrin α5ß1 at the plasma membrane of colorectal cancer-derived epithelial cells modulated their ability to respond to stimulation by receptor tyrosine kinase-activating growth factors EGF, NRG and HGF, through GSK3-mediated suppression of Akt pathway.
[integrative Biology]
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