Continue reading “Daiichi Sankyo Announces Clinical Trial Collaboration with AstraZeneca to Evaluate Patritumab Deruxtecan (U3-1402) in Combination with TAGRISSO in EGFR-Mutated Non-Small Cell Lung Cancer”
Daiichi Sankyo Company, Limited announced that it has entered into a clinical trial collaboration with AstraZeneca to evaluate the combination of patritumab deruxtecan, a HER3 directed DXd antibody drug conjugate, and TAGRISSO, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with EGFR-mutated advanced or metastatic non-small cell lung cancer.
[Daiichi Sankyo Company, Limited]
Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
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The authors demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
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Chen, Y., Niu, J., Li, L., Li, Z., Jiang, J., Zhu, M., Dong, T., Zhang, J., Shi, C., Xu, P., Lu, Y., Jiang, Y., Liu, P., & Chen, W. (2020). Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway. Life Sciences, 118158. https://doi.org/10.1016/j.lfs.2020.118158 Cite
Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
Evidence of small cell transformation was observed in all metastatic sites at autopsy, with inactivation of RB1 and TP53, and loss of ROS1 fusion expression.
[npj Precision Oncology]
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Lin, J. J., Langenbucher, A., Gupta, P., Yoda, S., Fetter, I. J., Rooney, M., Do, A., Kem, M., Chang, K. P., Oh, A. Y., Chin, E., Juric, D., Corcoran, R. B., Dagogo-Jack, I., Gainor, J. F., Stone, J. R., Lennerz, J. K., Lawrence, M. S., Hata, A. N., … Shaw, A. T. (2020). Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition. Npj Precision Oncology, 4(1), 1–8. https://doi.org/10.1038/s41698-020-0127-9 Cite
Scientists revealed an important role for EGFR–AKT–FOXO1–KLF6–E-cadherin axis in mutant p53-induced cell migration and tumor metastasis.
[Cell Death & Disease]
The authors investigated the ability of novel anti‐cancer agents, Dp44mT and DpC, to overcome androgen resistance. The effect of Dp44mT and DpC on androgen‐dependent and independent androgen receptor signaling was assessed in androgen‐dependent and ‐independent prostate cancer cells using 2D‐ and 3D‐tissue culture.
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Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
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Researchers demonstrated that hotspot mutant p53, p53-R273H, promoted cell scattering growth and migration via inhibiting the expression of Krupple-like factor 6 (KLF6), a Zinc finger transcription factor and a documented tumor suppressor.
[Cell Death & Disease]
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The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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The expression of UGT2B15, UGT2B17, de novo methyltransferases, DNMT3A and DNMT3B was assessed in prostate cancer cells treated with EGF, an EGFR inhibitor PD16893, and the methyltransferase inhibitor, 5-azacytidine, respectively.
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Researchers showed that human cytomegalovirus induced chronic and functional EGFR signaling that was distinct to the virus as compared to the natural EGFR ligand: EGF.
[Proceedings of the National Academy of Sciences of the United States of America]
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Fulkerson, H. L., Chesnokova, L. S., Kim, J. H., Mahmud, J., Frazier, L. E., Chan, G. C., & Yurochko, A. D. (2020). HCMV-induced signaling through gB–EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2003549117 Cite