The authors critically analyse the mechanisms of epidermal growth factor receptor expression in non-small cell lung cancer (NSCLC), its relevance to currently approved targeted treatment options, and the complex nature of secondary mutations and intrinsic and acquired resistance patterns in NSCLC.
7753456 AXIXMHDJ items 1 apa default asc 1
The role of mini-chromosome maintenance 8 (MCM8) in glioblastomas has remained unclear. Scientists investigated the biological functions and mechanisms of MCM8 in glioma stem cells.
6445212 T63UKVBZ items 1 apa default asc 1
Researchers characterized the clinicopathological features, including prognosis, of gastric carcinomas with copy number gains in multiple protooncogenes.
6445212 WW82V53X items 1 apa default asc 1
Scientists used quantitative mass spectrometry to characterize intrinsic changes in the muscle stem cell (MuSC) proteome and remodeling of the MuSC niche during aging.
6445212 XQSHYQ42 items 1 apa default asc 1
In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.
6445212 7688MQAA items 1 apa default asc 1
The authors observed waves of extracellular-signal-regulated kinase (ERK) and AKT serine/threonine kinase (Akt) activity pulses that originate from apoptotic cells and propagate radially to healthy surrounding cells. This requires epidermal growth factor receptor (EGFR) and matrix metalloproteinase signaling.
6445212 KNUS5UQD items 1 apa default asc 1
Investigators showed that while ablation of ADAM17 resulted in decreased shedding of TNF RI, ADAM10 deficiency led to increased levels of soluble TNF RI in serum.
7753456 8MZF2UWG items 1 apa default asc 1
Researchers examined the ability of patient-derived organoids to predict clinical responses to targeted therapies in individual patients and to identify effective anti-cancer therapies for novel molecular targets.
[Clinical Cancer Research]
6445212 GC2RF627 items 1 apa default asc 1
Modeling clinical responses to targeted therapies by patient-derived organoids of advanced lung adenocarcinoma | Clinical Cancer Research. (n.d.). Retrieved June 4, 2021, from https://clincancerres.aacrjournals.org/content/early/2021/06/03/1078-0432.CCR-20-5026 Cite
The authors carried out high-throughput functional screening using impedancemetry, and identified five miRNAs with potential antiproliferative or chemosensitive effects on SW1353 chondrosarcoma cells.
[International Journal of Molecular Sciences]
6445212 8J4VHC8C items 1 apa default asc 1
Veys, C., Benmoussa, A., Contentin, R., Duchemin, A., Brotin, E., Lafont, J. E., Saintigny, Y., Poulain, L., Denoyelle, C., Demoor, M., Legendre, F., & Galéra, P. (2021). Tumor Suppressive Role of miR-342-5p in Human Chondrosarcoma Cells and 3D Organoids. International Journal of Molecular Sciences, 22(11), 5590. https://doi.org/10.3390/ijms22115590 Cite
Pooled fitness screens in two breast cancer cell lines revealed peptides, which selectively reduced cellular proliferation, implicating oncogenic protein domains important for cell fitness.
6445212 I6INMQ4D items 1 apa default asc 1
The clustering of integrin α5ß1 at the plasma membrane of colorectal cancer-derived epithelial cells modulated their ability to respond to stimulation by receptor tyrosine kinase-activating growth factors EGF, NRG and HGF, through GSK3-mediated suppression of Akt pathway.
6445212 HTDFTD5G items 1 apa default asc 1