Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase

Human keratinocytes cells were used as an experimental model for studies on the effects of platelet-rich plasma on cell proliferation, migration, collagen biosynthesis, prolidase activity, and its expression and anabolic signaling.
[International Journal of Molecular Sciences]
Misiura, M., Guszczyn, T., Oscilowska, I., Baszanowska, W., Palka, J., & Miltyk, W. (2021). Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase. International Journal of Molecular Sciences, 22(2), 936. https://doi.org/10.3390/ijms22020936 Cite
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Genomic Profiles and Tumor Immune Microenvironment of Primary Lung Carcinoma and Brain Oligo-Metastasis

Scientists recruited 33 lung cancer patients with brain oligo-metastasis to explore the genomic features and tumor immune microenvironment of the lung and brain metastasis independently.
[Cell Death & Disease]
Song, Z., Yang, L., Zhou, Z., Li, P., Wang, W., Cheng, G., Chen, R., Chang, L., Zhang, Y., Guan, Y., Xia, X., Yi, X., Zhou, R., & Chen, M. (2021). Genomic profiles and tumor immune microenvironment of primary lung carcinoma and brain oligo-metastasis. Cell Death & Disease, 12(1), 1–10. https://doi.org/10.1038/s41419-021-03410-7 Cite
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Targeting Notch and EGFR Signaling in Human Mucoepidermoid Carcinoma

Scientists determined critical signaling for maintaining mucoepidermoid carcinoma (MEC) stem-like cells and the effect of combined targeting of stem cell signaling and CRTC1-MAML2-induced EGFR signaling on blocking MEC growth.
[Signal Transduction and Targeted Therapy]
Ni, W., Chen, Z., Zhou, X., Yang, R., Yu, M., Lu, J., Kaye, F. J., & Wu, L. (2021). Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma. Signal Transduction and Targeted Therapy, 6(1), 1–11. https://doi.org/10.1038/s41392-020-00388-0 Cite
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Antitumor Immunity Regulated by Aberrant ERBB Family Signaling

The authors discuss the mechanisms by which the signaling of ERBB family members affects not only autonomous cancer hallmarks, such as uncontrolled cell proliferation, but also antitumor immune responses in the tumor microenvironment and the potential application of immune-genome precision medicine into immunotherapy.
[Nature Reviews Cancer]
Kumagai, S., Koyama, S., & Nishikawa, H. (2021). Antitumour immunity regulated by aberrant ERBB family signalling. Nature Reviews Cancer, 1–17. https://doi.org/10.1038/s41568-020-00322-0 Cite
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Decorin-Mediated Suppression of Tumorigenesis, Invasion, and Metastasis in Inflammatory Breast Cancer

Overexpression of decorin in inflammatory breast cancer (IBC) cells markedly decreased migration, invasion, and cancer stem cells in vitro and inhibited tumor growth and metastasis in IBC xenograft mouse models.
[Communications Biology]
Hu, X., Villodre, E. S., Larson, R., Rahal, O. M., Wang, X., Gong, Y., Song, J., Krishnamurthy, S., Ueno, N. T., Tripathy, D., Woodward, W. A., & Debeb, B. G. (2021). Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-020-01590-0 Cite
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LncRNA TINCR Favors Tumorigenesis via STAT3–TINCR–EGFR-Feedback Loop by Recruiting DNMT1 and Acting as a Competing Endogenous RNA in Human Breast Cancer

The oncogenic role of TINCR was examined in vitro and in vivo in breast cancer. The interaction between TINCR, DNMT1, and miR-503-5p methylation was explored.
[Cell Death & Disease]
Wang, Q., Liu, J., You, Z., Yin, Y., Liu, L., Kang, Y., Li, S., Ning, S., Li, H., Gong, Y., Xu, S., & Pang, D. (2021). LncRNA TINCR favors tumorigenesis via STAT3–TINCR–EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03188-0 Cite
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The EGFR-HSF1 Axis Accelerates the Tumorigenesis of Pancreatic Cancer

Investigators clarified the mechanisms on early activation of heat shock factor 1 (HSF1) and its role in the pancreatic cancer tumorigenesis.
[Journal of Experimental & Clinical Cancer Research]
Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., Han, L., Li, L., Shen, X., Wu, Z., Ma, Q., & Wang, Z. (2021). The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 25. https://doi.org/10.1186/s13046-020-01823-4 Cite
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Targeting STAT3 by a Small Molecule Suppresses Pancreatic Cancer Progression

Researchers report a new small-molecule inhibitor with potent antitumor bioactivity, which inhibited multiple oncogenic processes in pancreatic cancer.
[Oncogene]
Chen, H., Bian, A., Yang, L., Yin, X., Wang, J., Ti, C., Miao, Y., Peng, S., Xu, S., Liu, M., Qiu, W.-W., & Yi, Z. (2021). Targeting STAT3 by a small molecule suppresses pancreatic cancer progression. Oncogene, 1–18. https://doi.org/10.1038/s41388-020-01626-z Cite
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Combining Neratinib with CDK4/6, mTOR and MEK Inhibitors in Models of HER2-Positive Cancer

Investigators explored the efficacy of neratinib in combination with inhibitors of downstream signaling in HER2+ cancers in vitro and in vivo.
[Clinical Cancer Research]
Zhao, M., Scott, S., Evans, K. W., Yuca, E., Saridogan, T., Zheng, X., Wang, H., Korkut, A., Pico, C. X. C., Demirhan, M. E., Kirby, B., Kopetz, S., Diala, I., Lalani, A. S., Piha-Paul, S., & Meric-Bernstam, F. (2021). Combining neratinib with CDK4/6, mTOR and MEK inhibitors in models of HER2-positive cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3017 Cite
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EGFR/SRC/ERK-Stabilized YTHDF2 Promotes Cholesterol Dysregulation and Invasive Growth of Glioblastoma

Scientists showed that YTHDF2 overexpression clinically correlated with poor glioma patient prognosis. EGFR that was constitutively activated in the majority of glioblastoma caused YTHDF2 overexpression through the EGFR/SRC/ERK pathway.
[Nature Communications]
Fang, R., Chen, X., Zhang, S., Shi, H., Ye, Y., Shi, H., Zou, Z., Li, P., Guo, Q., Ma, L., He, C., & Huang, S. (2021). EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nature Communications, 12(1), 177. https://doi.org/10.1038/s41467-020-20379-7 Cite
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EGFR Inhibitors Switch Keratinocytes From a Proliferative to a Differentiative Phenotype Affecting Epidermal Development and Barrier Function

The effects of Epidermal Growth Factor Receptor inhibitors (EGFRi) and Vascular Endothelial Growth Factor Receptor inhibitors at therapeutically relevant concentrations were assessed on proliferation and differentiation markers of human keratinocytes in a novel 3D micro-epidermis tissue culture model.
[BMC Cancer]
Joly-Tonetti, N., Ondet, T., Monshouwer, M., & Stamatas, G. N. (2021). EGFR inhibitors switch keratinocytes from a proliferative to a differentiative phenotype affecting epidermal development and barrier function. BMC Cancer, 21(1), 5. https://doi.org/10.1186/s12885-020-07685-5 Cite
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